Treatment Overview
Collagen PN Therapy is a Korean combination skin booster protocol that merges polynucleotides (PN/PNN) from purified salmon DNA with collagen-stimulating agents to provide deep regeneration, elasticity restoration, and anti-aging repair.
While PN/PNN works at the cellular and DNA level to repair damaged skin, the collagen stimulators enhance dermal thickness and elasticity, making this therapy one of Korea’s most comprehensive anti-aging solutions.
It belongs to the Skin Booster Combination Therapy family (Aqua Shine BTX, PN + PRP, PN + Exosomes, HA + PN):
- Collagen PN Therapy: Best for elasticity, firmness, and structural repair.
- Other combinations: Focus on hydration, scars, pigmentation, or oil control.
Purpose & Benefits
- DNA Repair: PN/PNN rejuvenates cells and improves skin resilience.
- Collagen Production: Stimulates fibroblasts to restore elasticity.
- Wrinkle Reduction: Softens fine lines and deeper folds.
- Skin Firmness: Improves dermal thickness for sagging or thinning skin.
- Scar & Texture Repair: Reduces acne scars, atrophic scars, and stretch marks.
- Hydration & Glow: Enhances skin plumpness and radiance.
- Synergy with Other Boosters: PN repairs and collagen stimulators rebuild structure, while HA or exosomes may be added for hydration or antioxidant protection.
Ideal Candidates
Collagen PN Therapy in Korea is recommended for:
- Adults in their 30s–60s with loss of elasticity, sagging, or aging skin.
- Patients with wrinkles, acne scars, or dermal thinning.
- Men and women comparing Collagen PN vs other combination boosters:
- Collagen PN Therapy: Best for elasticity and structural firmness.
- Aqua Shine BTX: Best for pore control and glow.
- Rejuran + PRP: Best for DNA repair and healing.
- Exosome Boosters: Best for antioxidant and cellular rejuvenation.
- Those seeking a non-surgical alternative to lifting or firming treatments.
Possible Risks & Complications
Collagen PN Therapy is safe in Korea’s dermatology clinics, but minor side effects may occur:
- Redness or Pinpoint Bumps: Temporary, fade in 24–48 hours.
- Mild Bruising or Swelling: Common with collagen-based injections.
- Tightness or Sensitivity: May last 1–2 days.
- Rare Risks: Overcorrection or uneven firmness (minimized with expert care).
Surgical Techniques Used
Though non-surgical, Collagen PN Therapy requires advanced dermatology expertise:
- Micro-Injections: PN/PNN + collagen solution placed into dermis.
- Meso-Gun Delivery: Ensures even distribution across treatment areas.
- Targeted Mapping: Focused on sagging zones, wrinkles, and scars.
- Layered Application: May be combined with HA, PRP, or exosomes.
- Multi-Session Protocol: Typically 3–4 sessions spaced 3–4 weeks apart, with maintenance every 6–9 months.
Recovery & Aftercare
- Immediately: Redness, swelling, or injection marks.
- 1–3 Days: Skin calms, hydration improves.
- 2–4 Weeks: Wrinkles soften, elasticity strengthens, scars reduce.
- Maintenance: Every 6–9 months for sustained results.
Aftercare Tips:
- Avoid makeup for 24 hours.
- Apply SPF 50+ daily.
- Use hydrating PN/HA-based serums.
- Avoid alcohol, saunas, or intense exercise for 1–2 days.
Results & Longevity
- Immediate: Skin feels hydrated and firmer.
- Short-Term (2–4 Weeks): Visible glow, softer wrinkles, improved tone.
- Medium-Term (2–3 Months): Collagen remodeling increases elasticity and density.
- Long-Term: Results last 6–9 months, prolonged with maintenance.
Treatment Process in Korea
- Consultation & Skin Analysis – Doctor evaluates skin elasticity, wrinkles, and scars.
- Preparation – Cleansing and numbing cream applied.
- Injection Session – PN + collagen booster delivered via micro-needle or meso-gun.
- Optional Add-On: HA, PRP, or exosomes for synergy.
- Post-Care: Cooling masks, LED therapy, soothing serums.
- Follow-Up: Multi-session protocol for best long-term results.
Why Korea is a Top Destination
- Korea is a pioneer in combination PN-based therapies.
- Clinics provide authentic, KFDA-approved PN/PNN + collagen injectables.
- Dermatologists are skilled in multi-layer regenerative protocols.
- Treatments are more affordable than Western medspas, with higher expertise.
- Seoul is globally recognized for firming, anti-aging, and regenerative skincare.
Cost Range (Detailed Breakdown)
Pricing for Collagen PN Therapy in Korea varies depending on clinic and package:
- Single Session (full face): USD 300 – 600
- 3-Session Package (recommended): USD 900 – 1,500
- Collagen PN + PN/HA Combo: USD 700 – 1,500 per session
- Luxury Anti-Aging Package (Collagen PN + Rejuran/Plinest + PRP/Exosomes): USD 2,500 – 4,000
Additional Costs in Korea:
- Consultation: USD 20 – 50
- Numbing & post-care: USD 20 – 40
- Add-ons (PDO threads, PRP, exosomes): USD 200 – 800
💡 Patients often call Collagen PN Therapy the “elasticity booster”, while other combination boosters are known for glow, hydration, or pigmentation repair. Together, they deliver structural repair plus radiant skin rejuvenation.
Popular Clinics
- Banobagi Dermatology (Seoul): Offers Collagen PN with PRP or Rejuran.
- Oracle Dermatology (Seoul): Combines Collagen PN with HA or exosome boosters.
- Renewme Skin Clinic (Seoul): Specializes in anti-aging and scar repair with PN boosters.
- View Plastic & Dermatology (Seoul): Provides Collagen PN with lifting protocols.
- Chaum Anti-Aging Center (Seoul): Premium PN + collagen regeneration packages.



