The Role of Polynucleotides (PN) in Medical Skin Regeneration: A Look at Rejuran Healer

A Comprehensive Look at Rejuran Healer in Korea

Medical skin regeneration has rapidly evolved thanks to breakthroughs in biotechnologies, and one of the most promising innovations is the use of polynucleotides (PNs). Central to this revolution is Rejuran Healer, a cutting-edge injectable treatment from Korea that harnesses the power of PNs to rejuvenate and repair damaged skin at a cellular level.

In this article, we’ll explore the science behind PNs, how Rejuran Healer works, and why Korean dermatology clinics are leading the way in this regenerative therapy.


🔍 What Are Polynucleotides (PN)?

Polynucleotides are long chains of nucleotides, the basic structural units of DNA and RNA. In medical skin regeneration, PNs are typically derived from highly purified salmon DNA and processed into injectable formulations. They have been extensively studied for their wound healing, anti-inflammatory, and cell repair properties.

Key Properties of PNs in Skin Regeneration:

  • Stimulate Fibroblast Activity: PNs activate fibroblasts, the cells responsible for producing collagen and elastin—essential proteins for skin strength and elasticity.
  • Modulate Inflammation: By regulating inflammatory cytokines, PNs reduce chronic skin inflammation, which contributes to aging and skin damage.
  • Promote Angiogenesis: PNs enhance the formation of new blood vessels, improving skin oxygenation and nutrient supply.
  • Improve Hydration: They help restore the skin’s natural moisture barrier, reducing dryness and roughness.
  • Accelerate Wound Healing: PNs speed up tissue regeneration and reduce scar formation.

🩺 How Does Rejuran Healer Use Polynucleotides?

Rejuran Healer is a polynucleotide-based injectable treatment that leverages these biological effects to improve skin health. Manufactured with strict purification processes in Korea, Rejuran contains high concentrations of PNs designed to:

  • Repair sun-damaged or aging skin by stimulating natural regeneration.
  • Enhance collagen and elastin synthesis to restore firmness and reduce fine lines.
  • Improve skin texture and elasticity for a youthful, glowing complexion.
  • Reduce pigmentation and redness associated with inflammation or aging.

Rejuran’s unique formula is combined with hyaluronic acid in some variations (such as Rejuran I and Rejuran HB) for enhanced hydration and skin barrier repair.


🌟 Why Is Rejuran Healer Popular in Korean Clinics?

Korea’s advanced dermatology and cosmetic medicine sector embraces innovation and safe, minimally invasive treatments. Rejuran Healer is a favorite among Korean clinics because:

  • It aligns with Korean beauty philosophy: natural, gradual skin improvement rather than drastic changes.
  • Proven clinical efficacy: numerous studies and patient cases from Korea demonstrate visible improvement in skin quality.
  • Versatility: effective for various skin concerns including aging, acne scars, dryness, pigmentation, and sensitive skin.
  • Minimal downtime: treatment sessions are quick, with mild side effects and rapid recovery.

📊 Clinical Evidence Supporting PN-Based Rejuran Treatment

  • Collagen Synthesis: Studies have shown Rejuran increases type I and III collagen in the dermis, which restores skin thickness and elasticity.
  • Anti-Inflammatory Effects: PN injections downregulate inflammatory mediators like IL-6 and TNF-alpha, improving conditions like rosacea, acne scars, and sensitive skin.
  • Wound Healing Enhancement: Research confirms PNs accelerate epithelial regeneration, making Rejuran useful post-procedures like laser resurfacing or microneedling.
  • Pigmentation Improvement: PN’s antioxidant properties help reduce hyperpigmentation by neutralizing free radicals in UV-damaged skin.

🧴 Typical Treatment Protocol in Korean Clinics

StepDetails
ConsultationSkin analysis with imaging (VISIA, cutometer)
Injection SessionsUsually 3 sessions spaced 3-4 weeks apart
CombinationOften combined with lasers, microneedling, or fillers for synergistic effects
MaintenanceEvery 6-12 months depending on skin condition

💡 Who Can Benefit Most from PN Therapy With Rejuran?

  • Patients with early to moderate skin aging looking to restore natural glow
  • Individuals with acne scars or post-inflammatory pigmentation
  • Those with sensitive or damaged skin requiring gentle regeneration
  • Burn survivors or trauma patients with scarring or poor wound healing
  • Anyone seeking hydration and skin barrier repair without invasive surgery

🏥 Leading Korean Clinics Using Rejuran Healer

Clinic NameSpecializationLocation
Banobagi Plastic SurgeryAdvanced regenerative therapiesSeoul, Apgujeong
Oracle ClinicAcne scar and anti-aging expertGangnam
ME ClinicCombination aesthetic treatmentsJongno, Seoul
CNP Skin ClinicSensitive skin and hydrationMyeongdong

🌟 Future Perspectives: The Growing Role of Polynucleotides in Aesthetic Medicine

As research advances, PN-based therapies like Rejuran Healer are expanding their indications beyond anti-aging to include:

  • Scar remodeling (hypertrophic, acne, surgical scars)
  • Hair follicle regeneration for alopecia
  • Adjunctive therapy for dermatologic conditions such as eczema or psoriasis
  • Post-procedure recovery for enhanced healing and reduced downtime

✅ Conclusion

Polynucleotides represent a groundbreaking frontier in medical skin regeneration, and Rejuran Healer exemplifies this technology’s potential. By promoting natural healing, reducing inflammation, and restoring the skin’s structural integrity, Rejuran offers patients in Korea and worldwide a safe, effective, and natural-looking solution for skin rejuvenation.

Whether you are seeking treatment for aging, scarring, or chronic skin conditions, PN therapy through Rejuran Healer offers a scientifically backed and minimally invasive path to healthier, youthful skin.


Get Consultancy

More insights

The Plus Plastic Surgery for Breast Augmentation

Breast augmentation is one of the most popular cosmetic surgeries worldwide — and Korea has quickly become a leading destination for international patients seeking high-quality, natural-looking results. At The Plus Plastic Surgery in Seoul, patients from around the globe trust the clinic’s reputation for artistic precision, patient-centered care, and cutting-edge surgical techniques. Whether you’re looking to enhance volume, correct asymmetry, or restore your body after

Read more >

The Plus Plastic Surgery for Alar Reduction:Refine and Balance Your Nose in Seoul

A well-proportioned nose can dramatically enhance facial harmony and beauty. For individuals with wide or flared nostrils, alar reduction surgery offers a refined solution. At The Plus Plastic Surgery in Seoul, patients from around the world choose this specialized procedure to achieve a more elegant and balanced nasal appearance — with natural-looking results and minimal scarring. In this blog post, we’ll walk you through everything

Read more >

Bong Bong Plastic Surgery for Tummy Tuck

Stubborn belly fat, loose abdominal skin, and separated muscles can be frustrating issues — especially after weight loss, pregnancy, or aging. At Bong Bong Plastic Surgery in Korea, the Tummy Tuck (Abdominoplasty) is a highly effective body contouring procedure designed to restore a flat, smooth, and sculpted midsection. Known for delivering natural-looking, refined results with world-class care, Bong Bong has become a trusted destination for

Read more >