If you’re struggling with erectile dysfunction (ED) and searching for a non-surgical, drug-free solution, you may have come across the P-Shot®, also known as the Priapus Shot. This advanced treatment uses your body’s own regenerative power—platelet-rich plasma (PRP)—to improve blood flow, tissue repair, and sensitivity in the penis.
In this article, we provide a step-by-step breakdown of the P-Shot procedure from a medical patient’s perspective, including preparation, what happens during the treatment, and what to expect during recovery.
🧬 What Is PRP and How Does It Help ED?
Platelet-rich plasma (PRP) is a concentration of platelets and growth factors derived from your own blood. These bioactive proteins are known for their ability to:
- Stimulate angiogenesis (new blood vessel formation)
- Enhance nerve regeneration
- Improve smooth muscle and connective tissue repair
- Increase blood flow and sensitivity
In men with vasculogenic ED, which is caused by poor penile blood flow, PRP has been shown to restore natural erectile function without the need for daily pills.
⚙️ Step-by-Step: The P-Shot Procedure Explained
Here’s what to expect before, during, and after a P-Shot treatment, broken down into clear, actionable steps.
✅ Step 1: Initial Consultation
Before scheduling the procedure, you’ll meet with a men’s health or urology specialist to:
- Review your medical history and current medications
- Assess your erectile function (often using the IIEF questionnaire)
- Perform diagnostic tests (optional) such as penile Doppler ultrasound
- Determine if you’re a good candidate for PRP therapy
Patients with mild to moderate ED, particularly due to blood flow issues, tend to respond best.
✅ Step 2: Pre-Procedure Instructions
- Avoid NSAIDs (e.g., ibuprofen, aspirin) for 3–5 days before the procedure (they can interfere with platelet function)
- Stay well-hydrated
- Eat a light meal before your appointment
- Discuss any blood-thinning medications or supplements with your provider
You’ll also be advised about potential benefits, risks, and post-treatment expectations.
✅ Step 3: Blood Collection
- A small blood sample (10–20 mL) is drawn from your arm—similar to a routine blood test
- This sample is used to extract PRP using centrifugation—a process that separates platelets and plasma from red and white blood cells
The resulting PRP contains a 5–10x higher concentration of healing factors than regular blood.
✅ Step 4: Numbing and Preparation
- A topical anesthetic cream is applied to the penis to ensure comfort
- Numbing usually takes 15–30 minutes to take full effect
- Some providers may use a nerve block for added comfort, especially if you’re anxious about injections
Once numb, the area is cleaned and prepared for the PRP injections.
✅ Step 5: PRP Injection (The P-Shot Itself)
Using a very fine needle, the provider carefully injects the PRP into targeted areas of the penis, usually including:
- Corpora cavernosa (erectile chambers)
- Glans penis (in some protocols, to enhance sensitivity)
The entire injection process takes about 10–15 minutes. Most patients report only mild pressure or tingling, with minimal pain due to the anesthetic.
🧪 Some practices may use ultrasound guidance for precise PRP placement, although this is not always required.
✅ Step 6: Post-Treatment Care and Penis Pumping
Immediately after the injection:
- A penis pump is often used for 5–10 minutes to help distribute the PRP evenly and stimulate expansion of tissue
- You may be advised to continue daily use of the pump at home for 2–3 weeks, for 10–15 minutes/day
- This enhances results by improving circulation and tissue elasticity
🚫 Avoid sexual activity for at least 24–48 hours to allow the tissue to settle.
📅 Recovery Timeline: What to Expect After the P-Shot
| Timeframe | What You Might Experience |
|---|---|
| 0–48 hours | Mild soreness, swelling, or bruising (resolves quickly) |
| Week 1 | Early improvements in sensitivity or spontaneous erections |
| Week 2–4 | Improved blood flow, firmness, and performance |
| Week 6–12 | Peak effects—most men report increased stamina and confidence |
Most patients return to normal activities the same day and experience no downtime.
⏱️ How Long Do the Results Last?
- Results typically last 12–18 months
- Some men may benefit from a booster injection after 6–12 months
- Ongoing lifestyle factors—like managing diabetes, quitting smoking, and exercising—can help prolong results
🎯 Who Should Consider the P-Shot?
Ideal candidates include men who:
- Have mild to moderate vasculogenic ED
- Experience reduced penile sensitivity
- Want a natural alternative to ED medications
- Cannot tolerate PDE5 inhibitors (Viagra, Cialis) due to side effects or interactions
- Desire performance enhancement and increased confidence
❗The P-Shot may be less effective for men with severe ED, significant nerve damage, or psychological ED unless combined with other therapies.
🔬 Are There Any Risks or Side Effects?
The P-Shot is very safe, especially since it uses your own blood, minimizing the risk of allergy or rejection. Possible (but rare) side effects include:
- Minor bleeding or bruising at the injection site
- Temporary swelling or discomfort
- Mild irritation during urination (resolves quickly)
Serious complications are extremely rare when performed by a trained provider.
✅ Summary: The P-Shot Procedure at a Glance
| Step | Description |
|---|---|
| Consultation | Assess ED cause and treatment suitability |
| Blood Draw | 10–20 mL of your own blood collected |
| PRP Preparation | Blood spun in a centrifuge to isolate platelet-rich plasma |
| Numbing | Topical anesthetic applied to minimize discomfort |
| Injection | PRP injected into strategic areas of the penis |
| Post-Treatment | Pumping protocol and brief recovery period |
Final Thoughts
The P-Shot procedure offers a powerful, regenerative option for men who want to overcome erectile dysfunction without relying on pills or surgery. Backed by emerging clinical research and patient testimonials, PRP therapy has helped thousands of men regain confidence, sensation, and natural performance.
