Treatment Overview
Advanced Embryo Genomics represents the integration of cutting-edge genetic science and embryology to analyze embryos before implantation during in vitro fertilization (IVF). Through Preimplantation Genetic Testing (PGT), Korean fertility specialists can examine the embryo’s chromosomal and genetic composition to identify abnormalities and select embryos with the highest potential for a healthy pregnancy.
Korea has become a global leader in embryo genomics due to its technological innovation, precision laboratory standards, and multidisciplinary expertise. Clinics utilize next-generation sequencing (NGS), whole-genome amplification, and bioinformatic analysis to achieve near-perfect detection accuracy for chromosomal aneuploidies, single-gene mutations, and inherited disorders.
This approach ensures that only genetically normal embryos are transferred, improving IVF success rates, reducing miscarriage risk, and supporting family planning for couples with known genetic risks.
Purpose & Benefits
The goal of Advanced Embryo Genomics is to combine reproductive medicine with genomic precision to enhance fertility outcomes and prevent hereditary diseases.
Key benefits include:
- Improved pregnancy outcomes: Selection of genetically normal embryos increases implantation and live birth rates.
- Reduced miscarriage risk: Early detection of chromosomal abnormalities prevents failed pregnancies.
- Inherited disease prevention: Identifies embryos free from single-gene disorders in carriers of known mutations.
- Higher IVF efficiency: Minimizes repeated cycles and optimizes embryo transfer timing.
- Supports advanced maternal age pregnancies: Screens for age-related chromosomal errors such as trisomy 21 (Down syndrome).
- Gender-related disorder prevention: Allows sex-linked disease screening when medically indicated.
- Enhanced reproductive confidence: Provides peace of mind for couples with previous IVF failures or genetic histories.
Korean fertility laboratories offer state-of-the-art genomic screening integrated with personalized reproductive counseling, ensuring each couple receives a precise, ethical, and evidence-based fertility plan.
Ideal Candidates
Advanced Embryo Genomics and Preimplantation Genetic Testing are recommended for:
- Couples with recurrent miscarriages or failed IVF cycles.
- Women over 35 years of age, where chromosomal abnormalities become more likely.
- Carriers of genetic diseases (e.g., cystic fibrosis, thalassemia, BRCA mutations).
- Couples with known chromosomal translocations or genetic rearrangements.
- Families with a history of hereditary disorders who wish to prevent transmission.
- Patients using donor eggs or sperm, ensuring genetic compatibility and health.
- Cancer survivors seeking embryo screening before pregnancy post-treatment.
In Korea, fertility centers tailor PGT programs to the individual’s genetic profile, reproductive history, and clinical goals.
Possible Risks & Complications
While advanced genomic testing is highly accurate and safe, there are some considerations:
- Embryo biopsy risk: Minimal damage may occur to the embryo during trophectoderm cell sampling, though this is rare with Korean micro-manipulation precision.
- Mosaicism: Some embryos may show mixed normal and abnormal cells, requiring careful interpretation.
- Ethical and emotional concerns: Decisions regarding embryo selection can be emotionally challenging.
- False positives or negatives: Extremely rare due to advanced technology, but possible in complex cases.
- Cost: High-end genomic sequencing and data analysis increase treatment costs.
Korean clinics mitigate these risks with high-resolution imaging, robotic micro-tools, and double-verification of genetic results by multidisciplinary genetics teams.
Techniques & Laboratory Methods
1. Next-Generation Sequencing (NGS)
- High-throughput DNA sequencing detects chromosomal abnormalities (aneuploidy, deletions, duplications).
- Allows genome-wide analysis with single-cell resolution.
- Provides highly detailed chromosomal mapping for PGT-A (aneuploidy testing).
2. Array Comparative Genomic Hybridization (aCGH)
- Earlier but still reliable platform comparing embryo DNA to normal reference samples.
- Used in combination with NGS for confirmation in some Korean centers.
3. Polymerase Chain Reaction (PCR) & Whole-Genome Amplification (WGA)
- Amplifies minimal embryo DNA from biopsied cells for full sequencing.
- Ensures accurate detection of mutations and chromosomal variants.
4. PGT-A (Preimplantation Genetic Testing for Aneuploidy)
- Screens for extra or missing chromosomes linked to miscarriage or syndromes such as Down, Turner, or Edwards.
5. PGT-M (Monogenic/Single-Gene Disorder Testing)
- Detects specific inherited mutations, preventing transmission of single-gene diseases.
6. PGT-SR (Structural Rearrangement Testing)
- Identifies unbalanced chromosomal rearrangements (e.g., translocations) that may cause infertility or developmental abnormalities.
7. AI-Integrated Embryo Analysis
- Artificial intelligence assists in correlating genomic data with embryo morphology and developmental potential.
- Korean labs employ AI-driven embryo ranking algorithms to select the healthiest candidates for transfer.
These techniques exemplify Korea’s advanced genomic capabilities in fertility medicine, delivering unmatched precision in embryo selection.
Recovery & Aftercare
Embryo genomics and PGT are minimally invasive procedures performed during the IVF process.
Post-Procedure Care:
- Embryo culture and cryopreservation: After biopsy, embryos are vitrified while awaiting genomic results.
- No patient downtime: The process is laboratory-based and does not affect patient recovery.
- Genetic counseling: Couples receive detailed explanation of PGT results from geneticists and fertility specialists.
- Personalized embryo transfer plan: Once genetically normal embryos are identified, transfer is scheduled during a hormonally optimal cycle.
- Emotional support: Counseling available for decision-making regarding embryo selection and family planning.
Korean fertility centers emphasize compassionate, informative aftercare to help patients understand genetic outcomes and make empowered reproductive decisions.
Results & Longevity
Korean fertility centers demonstrate world-leading success with advanced embryo genomics and PGT:
- Pregnancy rates: 65–75% per embryo transfer using genetically normal embryos.
- Reduced miscarriage rates: 50–70% lower compared to non-tested transfers.
- Live birth rates: Comparable to global best standards, exceeding 60% in some programs.
- Genetic accuracy: Over 99% reliability in chromosomal and single-gene diagnosis.
- Healthy baby outcomes: Nearly all births result in genetically and developmentally normal infants.
Korea’s integration of embryology, genomics, and artificial intelligence has positioned its fertility programs at the forefront of modern reproductive medicine.
Treatment Process in Korea
Step 1 – Genetic Consultation & IVF Planning
- Comprehensive assessment of patient genetics, reproductive goals, and risk factors.
- Personalized IVF and PGT plan created by fertility specialists and geneticists.
Step 2 – Ovarian Stimulation & Egg Retrieval
- Standard IVF stimulation performed using advanced, hormone-optimized protocols.
- Mature eggs collected and fertilized through intracytoplasmic sperm injection (ICSI).
Step 3 – Embryo Development & Biopsy
- Embryos cultured to the blastocyst stage (day 5–6).
- Trophectoderm biopsy performed by precision micromanipulation under a microscope.
Step 4 – Genetic Analysis
- Extracted cells analyzed using next-generation sequencing (NGS) and bioinformatics.
- Results indicate chromosomal integrity and genetic status.
Step 5 – Embryo Selection & Transfer
- Only chromosomally and genetically normal embryos are selected for uterine transfer.
- Transfer occurs in a natural or hormone-prepared cycle.
Step 6 – Cryopreservation & Long-Term Storage
- Remaining viable embryos are vitrified using ultra-rapid freezing with enhanced stability protocols.
Why Korea Excels
- Next-generation sequencing infrastructure with rapid analysis turnaround.
- Comprehensive fertility-genomics integration, uniting embryologists, geneticists, and AI specialists.
- High laboratory standards ensuring safe biopsy and storage conditions.
- Patient-centered genomic counseling, blending ethical, scientific, and emotional guidance.
- Cutting-edge AI and machine learning applications to enhance embryo grading accuracy.
- International reputation for precision and success in genetic IVF treatments.
Korea’s holistic model merges technology, ethics, and patient care — providing some of the most accurate and advanced embryo genomic services in the world.
Cost Range
The cost of Advanced Embryo Genomics and PGT in Korea depends on testing complexity, number of embryos analyzed, and clinic type. Typical estimates include:
- Preimplantation Genetic Testing (PGT-A): USD 4,000 – 6,000
- Single-Gene Testing (PGT-M): USD 5,000 – 7,500
- Structural Rearrangement Testing (PGT-SR): USD 5,000 – 8,000
- Comprehensive Genomic Package (including IVF, biopsy, and cryopreservation): USD 8,000 – 12,000
- Genetic Counseling and Consultation: USD 300 – 500
Korean fertility centers offer transparent packages combining IVF, genetic testing, and embryo storage in one integrated plan, often at lower costs than comparable Western programs.
Popular Clinics in Korea
- CHA Fertility Center (Seoul, Bundang): Global pioneer in PGT and embryo genomic technology.
- Maria Fertility Hospital: Known for AI-assisted embryo screening and high success in genetic IVF.
- MizMedi Women’s Hospital: Offers full-spectrum genetic testing and family-planning genomics.
- Hamchoon Women’s Clinic: Specializes in NGS-based embryo diagnostics and individualized fertility solutions.
- Seoul National University Hospital – Fertility Center: Advanced genomic lab integrated with academic research and international patient services.
