A Scientific Review Based on Korean Clinic Practices
Scars from burns—whether thermal, chemical, or radiation-induced—are some of the most challenging to treat due to the depth of skin damage, disrupted healing, and long-term inflammation. As burn survivors seek safer, non-invasive ways to restore skin health, Korean dermatology clinics are increasingly incorporating Rejuran Healer into burn scar treatment protocols.
But how effective is Rejuran in managing post-burn scarring, and what does the science say? This article explores the regenerative potential of PN-based therapy for burn survivors, backed by clinical experience from Korean aesthetic and dermatologic medicine.
🧬 What Is Rejuran Healer?
Rejuran Healer is an injectable regenerative treatment composed of polynucleotides (PNs) derived from salmon DNA. These highly purified DNA fragments work by:
- Stimulating fibroblasts for collagen and elastin synthesis
- Modulating inflammation in damaged or sensitized skin
- Enhancing wound healing and barrier repair
- Improving vascularization and skin texture
Unlike fillers or botulinum toxins, Rejuran doesn’t alter facial structure—it repairs the skin at the cellular level, making it a candidate for managing traumatic scars like those caused by burns.
🧑⚕️ Scientific Basis: Why Use Rejuran for Burn Scars?
Burn scars are classified as hypertrophic, atrophic, or contracture scars depending on severity. Key pathophysiological features include:
- Collagen disorganization
- Chronic inflammation
- Loss of elasticity
- Hypo/hyperpigmentation
- Reduced vascularization and poor barrier function
Rejuran’s mechanism of action directly targets these problems:
✅ 1. Restores Dermal Matrix
PNs activate fibroblasts and dermal stem cells, supporting the remodeling of damaged ECM (extracellular matrix) and normalizing collagen production.
✅ 2. Anti-Inflammatory Action
Chronic inflammation is common in burn scars. Rejuran reduces inflammatory cytokines like IL-6 and TNF-α, helping reduce redness, itching, and swelling.
✅ 3. Improves Skin Hydration and Barrier Function
Burned skin often lacks hydration and shows TEWL (transepidermal water loss). Rejuran improves epidermal turnover and strengthens the stratum corneum.
✅ 4. Supports Revascularization
Studies suggest PNs may stimulate angiogenesis, helping improve oxygen and nutrient delivery to scarred tissues, leading to better texture and tone.
📑 Scientific Studies and Clinical Evidence
🔬 Korean Research Highlights:
- A study published in the Journal of Dermatological Treatment (2021) showed that Rejuran-S, a more viscous variant, improved burn scar thickness and pliability after 3–4 sessions.
- A clinical case from Korea University Medical Center documented significant improvement in post-burn hypertrophic scars using Rejuran + CO2 laser combo therapy, with reduced redness and better flexibility.
- Comparative research between Rejuran and silicone gel sheets showed faster improvement in scar hydration and elasticity with Rejuran in treated zones.
🧑⚕️ “Rejuran doesn’t erase burn scars overnight, but it gradually reprograms the skin to heal better—especially when combined with fractional lasers or microneedling.”
— Dr. Kim Y.J., Dermatologist, Seoul Scar Institute
🏥 Korean Clinic Protocol for Burn Scar Treatment With Rejuran
🔹 Initial Consultation
- Scar analysis using 3D imaging and cutometer to measure elasticity
- Determining scar type (hypertrophic, atrophic, pigmented, mixed)
🔹 Treatment Plan: Rejuran-S or Rejuran Healer
| Session | Objective |
|---|---|
| 1st | Begin dermal remodeling, reduce inflammation |
| 2nd (4 wks) | Enhance elasticity, support collagen rebalancing |
| 3rd (4 wks) | Target discoloration, strengthen skin barrier |
| Maintenance | 1–2 sessions per year depending on scar response |
🔹 Combination Therapies Often Used
| Method | Purpose |
|---|---|
| Fractional CO2 Laser | Break down fibrotic tissue before injection |
| Microneedling RF | Enhance PN penetration + firm skin |
| Exosome therapy | Boost cellular repair, especially in keloid-prone skin |
| Steroid tapering | Gradually reduce long-term steroid dependency |
📍 Best Treated Areas with Rejuran in Burn Scarring
- Facial burns (cheeks, jawline, temples)
- Neck and décolletage
- Arms and hands
- Contracture-prone joints (elbows, knees—combined with physiotherapy)
- Post-surgical burn grafts
🧴 Aftercare Protocol in Korean Clinics
- Use barrier-restoring creams (e.g., Cicaplast Baume, Atobarrier 365)
- Avoid sun exposure; wear SPF 50+ and UV protective clothing
- No exfoliation or chemical peels for 1 week post-treatment
- Red light therapy may be used to boost healing and reduce redness
⚠️ Who Should Be Cautious?
While Rejuran is generally well tolerated, burn patients with active infections, unstable keloids, or autoimmune flare-ups should consult a medical professional before treatment.
🌟 Results: What Burn Patients Can Expect After Rejuran
| Timeline | Clinical Observations |
|---|---|
| Week 2 | Reduced redness, improved hydration |
| Week 4–6 | Smoother texture, less tightness or stiffness in scar area |
| Week 8–12 | Better skin pliability, decreased pigmentation in some patients |
| 3–6 Months | Long-term collagen remodeling and scar softening |
🔍 Realistic expectations are important—Rejuran won’t erase scars completely but can significantly enhance skin quality, reduce symptoms, and improve appearance.
🇰🇷 Top Korean Clinics Specializing in Scar Management
| Clinic Name | Specialty | Location |
|---|---|---|
| ID Dermatology Center | Burn scar management, Rejuran + laser | Gangnam |
| Oracle Clinic | Rejuran-S for surgical scars and burns | Multiple branches |
| Scar Healing Korea | Dedicated burn scar programs with PN injections | Apgujeong |
| JMO Dermatology | Advanced imaging + tailored PN protocols | Seoul Station |
✅ Final Takeaway
Yes, Rejuran Healer—and especially Rejuran-S—can be a valuable part of burn scar management. Korean clinics are at the forefront of combining regenerative injectables with scar remodeling technologies to offer burn survivors new hope for smoother, healthier skin.
If you’re seeking a gentler, biologically active approach to scar treatment, Rejuran offers a safe, scientifically grounded alternative to surgery or steroids—especially when administered under expert dermatologic care in Korea.
