Treatment Overview
Diane-35 is a hormonal therapy frequently prescribed in Korean dermatology clinics for women suffering from hormonal acne. It contains cyproterone acetate (anti-androgen) and ethinylestradiol (estrogen), which work together to regulate hormones, reduce excess sebum production, and prevent androgen-driven breakouts.
Hormonal acne often appears as deep, cystic pimples along the jawline, chin, and lower cheeks, triggered by menstrual cycles, stress, or conditions like PCOS. Diane-35 helps by blocking androgen activity, lowering oil output from sebaceous glands, and improving acne at its root cause. In Korea, dermatologists often prescribe Diane-35 alongside acne facials, chemical peels, or LED light therapy for comprehensive results.
Purpose & Benefits
- Regulates Hormones: Balances androgen activity, controlling hormonal acne flare-ups.
- Sebum Reduction: Decreases oil production, reducing clogged pores.
- Long-Term Acne Control: Prevents cyclical breakouts linked to menstruation.
- Skin Clarity: Improves acne-prone skin texture and reduces inflammation.
- Dual Benefits: Also helps regulate menstrual cycles and reduce androgen-related issues (such as oily skin or mild hirsutism).
Ideal Candidates
Diane-35 in Korea is recommended for:
- Women with moderate to severe hormonal acne, particularly around the jawline and chin.
- Patients with acne resistant to topical or antibiotic therapies.
- Individuals with acne linked to PCOS or androgen excess.
- Women seeking a long-term solution to cyclical acne flare-ups.
- Those looking for both acne control and hormone balance.
Possible Risks & Complications
Like all hormonal therapies, Diane-35 requires medical supervision. Potential risks include:
- Nausea, Breast Tenderness, or Mild Headaches (common, usually temporary).
- Weight or Mood Changes.
- Risk of Blood Clots (DVT/PE): Rare, but higher in women who smoke or have clotting disorders.
- Not Recommended in Pregnancy: Requires strict medical guidance.
Korean dermatologists carefully assess medical history and run necessary tests before prescribing Diane-35 to minimize risks.
Surgical Techniques Used
Diane-35 is not a surgical treatment but an oral prescription therapy. In Korea, dermatologists integrate it into multi-step acne programs:
- Oral Prescription: Diane-35 taken daily for 21 days, followed by a 7-day break.
- Combination Care: Paired with acne peels, LED red/blue light therapy, or acne drips.
- Monitoring: Patients undergo periodic follow-ups to ensure safety and effectiveness.
Recovery & Aftercare
1–2 Weeks: Skin oiliness begins to decrease.
1–2 Months: Hormonal acne flare-ups lessen in frequency and severity.
3–6 Months: Significant reduction in cystic acne, clearer and more balanced skin.
Aftercare Tips:
- Take medication consistently at the same time daily.
- Attend regular dermatologist check-ups for monitoring.
- Use SPF 50+ sunscreen daily to protect against pigmentation.
- Maintain a gentle skincare routine with non-comedogenic products.
- Avoid smoking or high-risk lifestyle habits to reduce clotting risks.
Results & Longevity
- After 1 Month: Reduced sebum activity and fewer breakouts.
- After 3 Months: Noticeably clearer skin and less inflammation.
- After 6 Months: Long-term hormonal balance and stable acne control.
Results typically last as long as therapy is continued. Many Korean dermatologists taper or switch to maintenance therapies once acne is controlled.
Treatment Process in Korea
Consultation & Hormonal Assessment
Dermatologist evaluates acne pattern, hormonal triggers, and medical history. Blood tests may be conducted to check hormone levels.
Prescription & Custom Plan
Diane-35 prescribed in low, monitored doses. Often combined with in-clinic acne treatments such as chemical peels, LED therapy, or Aqua Peel for synergistic effects.
Follow-Up & Monitoring
Patients return every 1–3 months for safety checks and adjustments. Korean dermatologists emphasize close monitoring to ensure maximum benefits with minimal side effects.
Why Korea is a Top Destination
- Integrated Approach: Korean clinics don’t just prescribe pills—they combine hormonal therapy with advanced acne procedures.
- Advanced Technology: Treatments like LED, Aqua Peel, and regenerative boosters enhance results.
- Scar Prevention Focus: Early intervention prevents acne from leaving scars.
- Personalized Care: Programs are tailored to individual hormonal cycles and skin type.
- Affordability & Accessibility: Diane-35 and supporting treatments are cost-effective compared to Western countries.
Cost Range (Estimated)
- Initial Consultation & Prescription: USD 30 – 70
- Monthly Diane-35 Medication: USD 20 – 40
- Combination Therapy (Diane-35 + Acne Peel/LED): USD 100 – 200 per month
Example Korean Packages:
- Standard Program (3 months): USD 250 – 400
- Acne Care Program (3–6 months with Diane-35 + Peels/LED): USD 500 – 900
- Premium Program (6 months with Diane-35 + regenerative boosters such as PDRN/Exosomes): USD 1,000 – 1,800
Popular Clinics in Seoul
- Oracle Dermatology: Hormonal acne programs with Diane-35 and acne facials.
- Banobagi Dermatology: Integrates oral therapy with chemical peels and scar prevention.
- Renewme Skin Clinic: Diane-35 combined with LED therapy and acne injections.
- View Dermatology: Multi-step hormonal acne packages with peels + oral therapy.
- Chaum Anti-Aging Center: Premium programs with Diane-35, supplements, and regenerative boosters.



