Treatment Overview
Endometrial Receptivity Analysis (ERA) is an advanced genetic test designed to determine the optimal time for embryo transfer during an IVF (In Vitro Fertilization) cycle. By analyzing gene expression in a sample of endometrial tissue, the test identifies whether the endometrium (uterine lining) is receptive, pre-receptive, or post-receptive, helping fertility specialists pinpoint the personalized window of implantation (WOI) unique to each woman.
In Korea, ERA has become a cornerstone of precision fertility medicine, widely performed in world-class fertility centers equipped with molecular diagnostic technology and AI-assisted analysis. Korean reproductive specialists integrate ERA testing into personalized IVF protocols to maximize implantation rates and pregnancy success for both local and international patients.
Purpose & Benefits
The Endometrial Receptivity Analysis is crucial for women undergoing IVF, particularly those who have experienced repeated implantation failure (RIF) despite transferring high-quality embryos.
Key Benefits Include:
- Determines the exact timing for embryo transfer (your personalized implantation window)
- Increases the success rate of IVF and embryo transfer
- Detects implantation window displacement, a common cause of failed IVF cycles
- Reduces trial-and-error in IVF scheduling
- Provides a genomic understanding of endometrial function
- Offers hope for women with unexplained infertility or repeated IVF failure
- Non-invasive beyond a minimally invasive biopsy and performed in a single menstrual cycle
Korean fertility centers have integrated ERA with other diagnostic tools such as hormone monitoring, 3D Doppler imaging, and endometrial thickness evaluation for a complete fertility picture.
Ideal Candidates
ERA testing is ideal for women who:
- Have undergone multiple unsuccessful IVF or embryo transfers
- Experience repeated implantation failure (RIF) despite good-quality embryos
- Are preparing for frozen embryo transfer (FET)
- Wish to personalize their fertility treatment schedule
- Have unexplained infertility or irregular cycles
- Want to optimize the chances of successful pregnancy on the first IVF attempt
In Korea, ERA is typically recommended after two or more failed IVF cycles or before advanced assisted reproduction procedures.
Possible Risks & Complications
The ERA test is very safe and well-tolerated. Minor, temporary effects may include:
- Mild cramping during or after the endometrial biopsy
- Light spotting for 1–2 days
- Slight discomfort due to uterine sensitivity
Korean fertility clinics perform the procedure under ultrasound guidance and local anesthesia, minimizing any pain or side effects. All testing adheres to international safety and ethical standards for reproductive medicine.
Diagnostic Techniques Used
ERA is a molecular diagnostic test based on RNA sequencing (transcriptomic analysis) of endometrial tissue to evaluate the expression of over 200+ genes associated with implantation readiness.
Advanced Diagnostic Steps Used in Korea:
- Endometrial biopsy on a specific day of the menstrual or hormone-stimulated cycle
- RNA extraction and sequencing to evaluate gene activity patterns
- AI-assisted algorithmic analysis to identify receptive status
- Integration with 3D Doppler uterine blood flow imaging for vascular assessment
- Receptivity report determining the precise implantation window
Korean fertility centers use state-of-the-art genetic laboratories and partner with leading biotech firms to ensure fast, accurate, and globally recognized ERA results.
Recovery & Aftercare
Recovery is quick, and patients can resume normal activities immediately after the procedure.
Aftercare Recommendations:
- Mild rest for the remainder of the day
- Avoid sexual activity for 1–2 days post-biopsy
- Follow up with your fertility specialist to review ERA results (typically within 2–3 weeks)
- Continue with IVF medication plan as prescribed
Korean clinics offer personalized embryo transfer scheduling based on the ERA findings in the following cycle, ensuring the best possible implantation timing.
Results & Interpretation
ERA testing categorizes the endometrial state into three possible outcomes:
- Receptive: The endometrium is ready for embryo implantation.
- Pre-Receptive: The uterine lining is not yet ready — embryo transfer should be delayed.
- Post-Receptive: The lining has passed its optimal implantation window — transfer should occur earlier.
Based on these results, Korean fertility specialists create a Personalized Embryo Transfer (pET) plan that aligns perfectly with the patient’s unique biological clock, significantly improving IVF success rates.
Testing Process in Korea
Korea is a global leader in fertility genomics and personalized reproductive medicine, offering advanced ERA testing with superior accuracy and turnaround times.
Typical ERA Testing Process:
- Initial fertility consultation and hormone cycle review.
- Endometrial biopsy performed on a specific day of the menstrual cycle (usually day 19–21).
- Sample sent to a specialized molecular laboratory for RNA sequencing.
- Results analyzed using AI-driven algorithms to determine receptivity status.
- Customized embryo transfer timing plan developed for the next IVF or FET cycle.
Why Korea is a Top Destination for ERA and Fertility Testing:
- Advanced reproductive genetics and molecular diagnostics
- World-class fertility specialists trained in personalized IVF protocols
- Integration of ERA with other fertility tests (EMMA, ALICE, PGT-A, Doppler imaging)
- High IVF success rates achieved through precise implantation timing
- International patient support with translation and customized treatment plans
Korea’s leading fertility hospitals combine technology, clinical expertise, and personalized care, setting new global standards in fertility evaluation and assisted reproduction.
Cost Range
The cost of Endometrial Receptivity Analysis in Korea varies depending on clinic and package inclusions.
- ERA Test Only: USD $800 – $1,200
- ERA + Endometrial Microbiome (EMMA/ALICE): USD $1,200 – $1,800
- Full Fertility Genetic Evaluation Package: USD $2,000 – $3,500, including hormone tests and embryo transfer planning
Most Korean fertility centers offer package discounts for IVF patients or combined ERA + embryo cryopreservation programs.
Popular Clinics in Korea for ERA Testing
CHA Fertility Center (Seoul): Global pioneer in genomic fertility testing, ERA, and personalized embryo transfer protocols.
Maria Fertility Hospital: Offers integrated ERA and EMMA analysis with IVF cycle synchronization.
MizMedi Women’s Hospital: Renowned for advanced endometrial receptivity testing and high IVF success rates.
Seoul National University Hospital – Fertility Center: Provides research-based reproductive genomics and ERA testing.
ID Women’s Health Center: Specializes in endometrial profiling, ERA-guided embryo transfers, and reproductive optimization.
