Treatment Overview
Endometrial Receptivity Analysis (ERA) is a groundbreaking test that determines the optimal time for embryo transfer by analyzing the gene expression of the endometrial lining. It identifies whether the uterus is receptive—ready to accept an embryo—during a woman’s cycle. In Korea, ERA is increasingly combined with Donor Egg IVF programs to maximize implantation success, particularly for patients who have experienced repeated IVF failures despite transferring high-quality embryos.
Korean fertility clinics utilize genomic sequencing, AI-enhanced data interpretation, and precision molecular diagnostics to pinpoint the exact implantation window, ensuring personalized and highly effective embryo transfer timing.
Purpose & Benefits
The main goal of Endometrial Receptivity Analysis is to synchronize embryo transfer with the uterus’s optimal receptivity phase, ensuring the embryo implants successfully.
Key benefits include:
- Determination of the personalized implantation window (PIW).
- Increased implantation and pregnancy rates in donor egg IVF cycles.
- Reduction of repeated implantation failure (RIF).
- Identification of hormonal or endometrial abnormalities that affect receptivity.
- Tailored embryo transfer scheduling for greater success precision.
Korean fertility centers use ERA to turn previously failed IVF cycles into successful pregnancies by customizing treatment timing at a molecular level.
Ideal Candidates
Endometrial Receptivity Analysis is ideal for:
- Women undergoing donor egg IVF or frozen embryo transfer (FET) cycles.
- Patients with repeated IVF or implantation failures.
- Women with normal embryos but unexplained infertility.
- Individuals with irregular menstrual cycles or endometrial disorders.
- International patients seeking a personalized fertility approach backed by scientific precision.
Even with high-quality donor eggs, implantation success depends on perfect uterine timing—ERA ensures this critical alignment.
Possible Risks & Complications
ERA is a safe and minimally invasive procedure. However, potential risks include:
- Mild discomfort or spotting after the endometrial biopsy.
- Rare chance of infection or cramping.
- Possible emotional stress while awaiting results.
Korean fertility specialists minimize risks through gentle biopsy techniques, sterile procedures, and supportive care. Results are usually ready within 1–2 weeks, allowing efficient scheduling of the next IVF cycle.
Surgical Techniques Used
ERA in Korea involves advanced molecular and genomic technologies, including:
- Endometrial Biopsy Sampling – A small tissue sample is taken from the uterine lining.
- RNA Sequencing & Gene Expression Profiling – Over 200 genes related to endometrial receptivity are analyzed.
- AI-Based Pattern Recognition – Predicts the optimal implantation window.
- Customized Embryo Transfer Protocols – Integrates results with IVF cycle management.
Clinics may combine ERA with Endometrial Microbiome Testing (EMMA) or Chronic Endometritis Analysis (ALICE) for a full diagnostic view of uterine health.
Recovery & Aftercare
Recovery from an ERA biopsy is quick, typically requiring only a few hours of rest. Most women experience mild cramping or spotting for 1–2 days. Aftercare includes:
- Light physical rest and avoiding strenuous activity.
- Follow-up consultation to review results and plan embryo transfer.
- Personalized hormone therapy or uterine preparation based on findings.
Korean clinics often provide holistic fertility aftercare, including nutritional advice, acupuncture, and stress-reduction therapies to optimize endometrial health.
Results & Longevity
ERA provides long-term diagnostic insight—once a woman’s receptivity pattern is established, it usually remains consistent for years. This means the results can be applied to future IVF or donor egg cycles, saving time and cost.
In Korea, ERA has been shown to increase implantation rates by 15–25% in patients with previous IVF failures. When combined with donor egg IVF, success rates often reach 70–80% per cycle, reflecting Korea’s precision-based approach to reproductive medicine.
Treatment Process in Korea
Korean fertility clinics perform Endometrial Receptivity Analysis with high precision and patient-centered care. The process typically includes:
- Preliminary Consultation – Assessment of patient history and IVF cycle details.
- Endometrial Biopsy Procedure – Performed during the luteal phase or mock cycle.
- Genetic Laboratory Analysis – AI-supported sequencing identifies receptivity timing.
- Result Interpretation – Doctor determines the patient’s personalized implantation window.
- Personalized Embryo Transfer – Transfer scheduled precisely to match the ideal window.
Korea’s fertility centers integrate ERA with PGT-tested embryos, AI scheduling tools, and real-time hormone tracking, offering unparalleled accuracy and efficiency. The country’s strong medical infrastructure, strict ethics, and international patient programs make it a top global destination for precision fertility treatments.
Cost Range
The cost of Endometrial Receptivity Analysis in Korea ranges from USD 800 to USD 1,800, depending on the clinic and whether additional tests (EMMA or ALICE) are included. When performed as part of a donor egg IVF package, total treatment costs may range between USD 18,000 and USD 30,000.
Despite its advanced genetic technology, ERA in Korea remains more affordable than similar services in the U.S. or Europe, while maintaining world-class standards.
Popular Clinics
- CHA Fertility Center (Seoul) – Known for pioneering ERA integration and AI-guided embryo transfer timing.
- Maria Fertility Hospital – Offers personalized implantation analysis and full genomic screening.
- MizMedi Women’s Hospital – Provides ERA, EMMA, and ALICE testing for international patients.
- GynART Reproductive Center – Specializes in precision embryo transfer and endometrial diagnostics.
- Seoul National University Hospital – Fertility Unit – Combines genomic analysis with research-driven reproductive medicine.
