Treatment Overview
The Immunologic Recurrent Miscarriage Test is a comprehensive diagnostic evaluation designed to detect immune system abnormalities that may cause recurrent pregnancy loss (RPL). In some women, the immune system mistakenly identifies the developing embryo as foreign and triggers an immune response, leading to implantation failure or miscarriage.
In Korea, immunologic testing for RPL is an advanced component of fertility diagnostics. Specialized fertility centers and immunology laboratories use cutting-edge assays, flow cytometry, and molecular diagnostics to assess immune tolerance, antibody levels, and inflammation markers that may interfere with normal pregnancy.
Purpose & Benefits
The primary purpose of immunologic testing is to identify immune-related factors that can lead to repeated pregnancy loss or implantation failure.
Key benefits include:
- Detecting immune abnormalities such as antiphospholipid antibodies, natural killer (NK) cell overactivity, or autoimmune disorders.
- Determining if the body is producing antibodies against the embryo or placenta.
- Identifying inflammatory markers that affect endometrial receptivity.
- Guiding tailored treatments such as immunotherapy, corticosteroids, IVIG (intravenous immunoglobulin), or anticoagulants.
- Preventing future pregnancy losses through early medical intervention and immune regulation.
Korean fertility centers integrate immunologic testing with hormonal, genetic, and anatomical evaluations to create a comprehensive RPL treatment plan, improving conception and live birth outcomes.
Ideal Candidates
Immunologic miscarriage testing is recommended for:
- Women with two or more consecutive miscarriages without a clear cause.
- Patients with failed IVF or repeated implantation failure.
- Individuals with autoimmune diseases, such as lupus, rheumatoid arthritis, or thyroiditis.
- Women with unexplained infertility after normal reproductive evaluations.
- Patients who have experienced pregnancy complications, such as preeclampsia or fetal growth restriction.
- Couples with previous pregnancies affected by placental dysfunction or early fetal demise.
This test helps identify whether immune dysfunction, rather than genetic or structural issues, is responsible for pregnancy loss.
Possible Risks & Complications
Immunologic testing is performed through blood sampling, so the risks are minimal. Possible issues include:
- Mild discomfort or bruising at the blood draw site.
- Rare allergic reaction to antiseptics or bandages.
- Emotional distress if abnormalities are detected.
- Need for repeat testing to confirm or track antibody changes.
Korean diagnostic laboratories follow strict safety and sample handling protocols, ensuring reliable results and minimal procedural discomfort.
Techniques & Tests Used
Korean fertility and immunology labs use advanced immunoassay and molecular technologies to detect and quantify various immune factors linked to miscarriage.
Common tests include:
- Antiphospholipid Antibody Panel: Tests for lupus anticoagulant, anticardiolipin, and anti-β2 glycoprotein I antibodies.
- Antinuclear Antibody (ANA) Test: Detects autoantibodies related to autoimmune disorders.
- Thyroid Autoantibody Test: Screens for anti-thyroglobulin and anti-TPO antibodies linked to miscarriage.
- Natural Killer (NK) Cell Assay: Measures NK cell number and activity, which can indicate excessive immune aggression.
- Cytokine Profile: Evaluates inflammatory mediators (e.g., TNF-alpha, IL-6, IL-10) affecting embryo implantation.
- HLA Compatibility Testing: Checks for immune compatibility between partners.
- Immunoglobulin and Complement Levels: Assesses immune balance and inflammation control mechanisms.
Korean laboratories use high-precision equipment, digital data systems, and internationally validated testing kits, ensuring reproducibility and accuracy.
Recovery & Aftercare
Since the test is non-invasive, recovery is immediate. Aftercare primarily involves reviewing results and implementing targeted treatments if needed:
- Consultation with an immunologist or fertility specialist to interpret results.
- If abnormal findings are detected, therapy may include:
- Low-dose aspirin or heparin to prevent clotting in antiphospholipid syndrome.
- Steroids or immunosuppressants to regulate autoimmune activity.
- IVIG (Intravenous Immunoglobulin) or intralipid therapy to modulate immune responses.
- Lifestyle and dietary adjustments to reduce inflammation.
- Regular monitoring during fertility treatment or early pregnancy to ensure immune stability.
Korean fertility clinics offer integrated care, combining immunologic treatment with ongoing fertility support.
Results & Longevity
- Results identify specific immune markers contributing to miscarriage risk.
- Positive results indicate the need for medical management before and during pregnancy.
- Once treated, patients often experience a significant reduction in miscarriage risk and improved implantation rates.
- Test results remain relevant for future pregnancies, though repeat testing may be done after immune therapy.
- Long-term prognosis is excellent when immune causes are recognized and managed early.
Korean specialists report high success rates in achieving successful pregnancies through immune-targeted therapies based on detailed testing.
Treatment Process in Korea
A typical immunologic miscarriage evaluation process in Korea includes:
- Initial Consultation: Detailed review of reproductive history and previous miscarriages.
- Blood Sample Collection: Performed under sterile conditions, typically early in the menstrual cycle.
- Laboratory Testing: Multiple panels are run to assess antibodies, immune cell function, and inflammation levels.
- Analysis & Reporting: Results are interpreted by immunologists and fertility specialists.
- Customized Treatment Plan: Based on results, therapy may include anticoagulants, immune-modulating medications, or hormonal support.
- Follow-Up & Monitoring: Repeat testing during fertility treatment and early pregnancy to ensure immune balance.
Why Korea is a Top Destination:
- Advanced immunology laboratories using AI-assisted analysis and molecular immunodiagnostics.
- Close collaboration between fertility specialists, immunologists, and reproductive endocrinologists.
- Personalized treatment protocols combining Western medical techniques and Korean integrative medicine for immune regulation.
- High success rates and rapid diagnostic turnaround times.
- Affordable, high-quality care with multilingual support for international patients.
Korea’s reproductive immunology programs are internationally recognized for their precision and patient-centered approach.
Cost Range
The cost of Immunologic Recurrent Miscarriage Testing in Korea depends on the number and complexity of tests performed:
- Basic Immune Panel (ANA, Antiphospholipid, Thyroid Antibodies): USD 200 – 400
- Comprehensive Reproductive Immunology Panel (NK cell, cytokine, HLA, complement): USD 600 – 1,200
- Full RPL Evaluation Package (including immunology, genetics, hormones): USD 1,500 – 2,500
- Follow-Up Testing: USD 100 – 300 per session
Many Korean fertility hospitals bundle immunologic testing within RPL diagnostic programs for greater value and efficiency.
Popular Clinics
Renowned hospitals and fertility centers in Korea offering advanced immunologic testing for recurrent pregnancy loss include:
- CHA Fertility Center (Seoul): Leading in reproductive immunology and immune-based fertility care.
- Maria Fertility Hospital: Provides integrated immunologic and hormonal testing for miscarriage prevention.
- MizMedi Women’s Hospital: Offers comprehensive immune, hormonal, and genetic evaluation for RPL.
- GynART Reproductive Center: Specializes in immune-based infertility treatment and monitoring.
- Seoul National University Hospital – Reproductive Medicine Unit: Pioneering immunologic fertility research and clinical application.
