Treatment Overview
Low-Dose Gonadotropin Stimulation Therapy in Korea is a specialized fertility treatment designed to help women with Polycystic Ovary Syndrome (PCOS) achieve ovulation safely and effectively. PCOS often causes irregular or absent ovulation due to hormonal imbalance, leading to infertility. This therapy involves administering small, carefully controlled doses of gonadotropins—hormones that stimulate the ovaries to produce mature eggs.
In Korean fertility centers, this treatment is performed under close ultrasound and hormonal monitoring to ensure precise follicle development while minimizing the risk of ovarian hyperstimulation syndrome (OHSS). The low-dose protocol is particularly effective for women with PCOS, as it promotes gentle, controlled ovarian stimulation rather than excessive follicular response.
Purpose & Benefits
The main purpose of Low-Dose Gonadotropin Therapy is to induce safe, single-egg ovulation in women with PCOS who have not responded to oral fertility medications such as clomiphene citrate or letrozole.
Key benefits include:
- Controlled ovarian stimulation, reducing the risk of multiple pregnancies
- Lower risk of OHSS compared to conventional high-dose protocols
- Improved ovulation and pregnancy rates for PCOS patients
- Precise adjustment of hormone dosage based on real-time monitoring
- Enhanced endometrial development for successful implantation
- Can be used alone or combined with intrauterine insemination (IUI) or IVF for higher success rates
Korean fertility specialists use individualized dosing strategies to ensure maximum safety, making this therapy one of the most trusted treatments for PCOS-related infertility.
Ideal Candidates
Low-Dose Gonadotropin Therapy is ideal for:
- Women with PCOS who do not ovulate with oral fertility medications
- Patients with irregular menstrual cycles or anovulation
- Women seeking to conceive with a low-risk, non-surgical fertility treatment
- Patients who wish to minimize complications while optimizing natural conception chances
- Women preparing for assisted reproductive techniques such as IUI or IVF
This treatment is suitable for PCOS patients with normal uterine structure and no major tubal blockages or severe male-factor infertility.
Possible Risks & Complications
Although the therapy is considered safe, close medical supervision is essential to prevent potential complications.
Possible risks include:
- Mild bloating or abdominal discomfort during stimulation
- Headaches or mood changes due to hormonal shifts
- Risk of multiple pregnancy if more than one follicle matures
- Ovarian Hyperstimulation Syndrome (OHSS) in rare cases
- Temporary fatigue or nausea during treatment
In Korea, fertility clinics maintain high safety standards by performing frequent ultrasounds and hormone tests to detect early signs of overstimulation and adjust doses accordingly.
Techniques & Methods Used
Low-Dose Gonadotropin Stimulation Therapy in Korea is a medically guided, step-by-step process aimed at achieving a balanced ovarian response.
Treatment methods include:
- Personalized Dosing Protocols: Small, individualized doses of gonadotropins (such as FSH or hMG) are administered daily to gently stimulate follicle growth.
- Step-Up or Step-Down Protocols: The dosage may be gradually increased (“step-up”) or decreased (“step-down”) based on the patient’s ovarian response.
- Monitoring and Adjustment: Regular ultrasound and blood tests measure follicle size, estradiol levels, and endometrial thickness to prevent overstimulation.
- Ovulation Triggering: When the dominant follicle reaches optimal size, an hCG or GnRH trigger injection is administered to induce ovulation.
- Timed Intercourse or IUI: Ovulation is coordinated with either natural intercourse or intrauterine insemination to maximize conception chances.
Korean fertility specialists use advanced imaging and lab technologies to ensure precise timing and safety throughout the stimulation process.
Recovery & Aftercare
Recovery from Low-Dose Gonadotropin Therapy is simple, as it is a non-surgical and outpatient treatment.
Aftercare recommendations include:
- Continue light physical activity and maintain hydration during the stimulation phase.
- Avoid high-impact exercise to prevent ovarian torsion during stimulation.
- Attend all scheduled monitoring appointments for hormone testing and ultrasounds.
- Follow post-ovulation instructions for intercourse or IUI timing.
- Report any unusual symptoms such as abdominal pain or bloating to the medical team immediately.
Korean clinics provide personalized follow-up support to ensure the patient’s well-being and track ovulation success after each cycle.
Results & Longevity
Low-Dose Gonadotropin Therapy offers excellent success rates in restoring ovulation and achieving pregnancy for PCOS patients.
Expected results include:
- Ovulation achieved in up to 85–90% of treatment cycles
- Pregnancy rates of approximately 20–30% per cycle when combined with timed intercourse or IUI
- Lower incidence of multiple pregnancies compared to standard-dose stimulation
- Minimal risk of ovarian hyperstimulation
- Improved hormonal regulation and menstrual regularity after treatment
Many patients experience continued ovulation even after therapy completion due to the hormonal reset effect achieved through stimulation.
Treatment Process in Korea
Korea’s fertility centers are known for their scientific precision, advanced monitoring systems, and patient-focused care.
The treatment process typically includes:
- Initial Consultation and Hormonal Assessment
Comprehensive hormone testing (FSH, LH, AMH, estradiol, progesterone) and pelvic ultrasound to evaluate ovarian function and readiness. - Customized Low-Dose Protocol Design
Fertility specialists determine the appropriate gonadotropin dosage and type based on the patient’s hormonal and metabolic profile. - Daily Hormone Injections and Monitoring
Patients receive small daily doses of injectable hormones while undergoing regular ultrasound scans and blood tests. - Ovulation Trigger and Fertility Procedure
Once the follicle reaches maturity, an hCG or GnRH trigger injection is administered to release the egg. Timed intercourse or IUI is then performed. - Follow-Up and Luteal Support
After ovulation, progesterone support is prescribed to enhance endometrial receptivity and support early pregnancy.
Why Korea is a Top Destination
Korea is internationally recognized for its excellence in fertility medicine, blending modern reproductive science with patient-centered care.
Reasons why Korea excels:
- Highly experienced fertility specialists with expertise in managing PCOS-related infertility
- Advanced hormone monitoring and imaging systems for precise cycle control
- Strict safety protocols that minimize complications
- Affordable treatment options with outcomes comparable to top global fertility centers
- Integration of modern medicine with traditional Korean wellness approaches to enhance success rates
Korean fertility clinics emphasize individualized care, precision, and emotional support, making them a preferred choice for international fertility patients.
Cost Range
The cost of Low-Dose Gonadotropin Stimulation Therapy in Korea varies depending on treatment length, medications, and monitoring frequency.
Typical cost range:
- Initial consultation and hormonal evaluation: ₩150,000–₩300,000
- Gonadotropin medication per cycle: ₩800,000–₩1,800,000
- Monitoring and ultrasound tests: ₩300,000–₩700,000
- Ovulation trigger injection and follow-up care: ₩200,000–₩400,000
- Total treatment cost per cycle: ₩1,500,000–₩3,000,000
This cost is significantly lower than in Western countries, while maintaining excellent medical quality and safety.
Popular Clinics in Korea
- CHA Fertility Center, Seoul: Renowned for advanced hormone therapy and PCOS-focused fertility care.
- MizMedi Women’s Hospital: Specializes in low-dose stimulation and ovulation management for PCOS patients.
- Maria Fertility Hospital: Offers customized hormonal treatment programs with high success rates.
- Ewha Womans University Medical Center: Provides integrative fertility care and advanced reproductive endocrinology.
- Banobagi Women’s Clinic: Combines hormonal therapy with personalized fertility optimization programs.
- Asan Medical Center Fertility Department: A leading center in hormonal therapy and advanced reproductive medicine.
