Treatment Overview
PDRN Scalp Mesotherapy is a popular regenerative scalp treatment in Korea that uses Polydeoxyribonucleotide (PDRN)—a DNA-based healing molecule extracted from salmon. PDRN is widely used in Korean dermatology for skin repair, tissue regeneration, and anti-inflammatory healing. Applied to the scalp through micro-injections, PDRN helps repair damaged follicles, improve scalp health, and stimulate a stronger growth environment.
Korean clinics prefer PDRN mesotherapy for patients experiencing thinning hair, weak follicles, chronic scalp inflammation, and early-stage hair loss. The treatment is minimally invasive, requires no downtime, and is often used as part of a multi-step hair regeneration program that may include exosomes, PRP, or peptide boosters.
Purpose & Benefits
PDRN Scalp Mesotherapy focuses on restoring scalp health at the cellular level. It is ideal for patients who need a healing-focused scalp treatment rather than a purely growth-stimulatory one.
Key Benefits
- Enhances scalp healing by stimulating DNA repair and tissue regeneration
- Reduces inflammation, itching, and scalp sensitivity
- Improves blood circulation in the dermal layer
- Strengthens weak or miniaturized follicles
- Improves scalp environment for better hair growth
- Increases collagen and elastin for better scalp elasticity
- Speeds recovery after FUE/FUT hair transplant
- Safe for sensitive scalps and long-term use
Ideal Candidates
Suitable For
- People with weak, fragile, or thinning hair
- Patients with early to mid-stage hair loss
- Individuals with scalp inflammation, redness, or dermatitis
- Those with poor scalp blood circulation
- Post–hair transplant patients
- Patients who cannot tolerate oral medications
- Anyone seeking a gentle, non-hormonal hair regeneration approach
Possible Risks & Complications
PDRN Mesotherapy is widely considered safe, especially in advanced Korean hair clinics. However, some mild side effects can occur.
Common, Mild Side Effects
- Redness
- Swelling
- Small temporary bumps
- Tenderness
- Itching
Rare Complications
- Minor bruising
- Allergic reactions (extremely rare due to high purity)
- Infection (very rare with proper sterilization)
Techniques & Technology Used
Korean clinics use advanced tools and delivery systems for safe and effective PDRN application.
Common Techniques
- Manual micro-injections with ultra-fine needles
- Mesogun devices (U225, Vital Injector 2)
- Customized PDRN + peptide cocktails
- Microchanneling for sensitive scalps
- Cryo-assisted mesotherapy for comfort
Premium brands like Rejuran HB, Rejuran Healer, and S-DNA are commonly used.
Treatment Process in Korea
1. Scalp Diagnosis
Digital trichoscopic imaging is used to assess follicles, inflammation, and scalp moisture.
2. Cleansing & Preparation
Deep scalp cleansing removes sebum and buildup.
3. Numbing Cream Application
Applied for 10–15 minutes to ensure comfort.
4. PDRN Injection Stage
PDRN is injected evenly into thinning or inflamed areas using manual technique or mesogun.
5. Soothing & Cooling
LED therapy or cooling masks calm the scalp.
6. Aftercare Advice
Patients can resume normal activities immediately with minimal restrictions.
Recovery & After-Care
Aftercare Tips
- Avoid washing hair for 6–12 hours
- No gym, sauna, or swimming for 24 hours
- Use gentle shampoo for a few days
- Do not scratch or irritate the scalp
- Use recommended serums or topical boosters
Most patients feel improvement in scalp hydration and comfort within days.
Results & Longevity
Expected Timeline
- 2–3 weeks: Reduced inflammation
- 4–6 weeks: Healthier, shinier hair
- 2–3 months: Fuller hair appearance
- 3–6 months: Stronger follicles & reduced shedding
Longevity
Results last 6–12 months, depending on individual scalp condition. Maintenance every 2–3 months is recommended for consistent improvement.
Why Korea Is a Top Destination
Benefits of Korea for This Treatment
- Premium PDRN brands like Rejuran
- Highly trained specialists
- State-of-the-art mesotherapy devices
- Affordable prices compared to the US/Europe
- Combination therapy options for superior results
- English-speaking coordinators for international patients
Cost of PDRN Scalp Mesotherapy in Korea
Average Price
- Per session: 120,000 – 350,000 KRW
- Packages (3–5 sessions): 300,000 – 900,000 KRW
Premium clinics using Rejuran may cost slightly more.
Popular Clinics in Korea
- Wonjin Dermatology (Gangnam) – Known for advanced hair regeneration
- Motion Clinic – Popular among medical tourists
- Oracle Dermatology – Nationwide chain, English-friendly
- Namu Plastic Surgery Clinic – Specializes in regenerative therapy
- Rehair Clinic Korea – Expert in mesotherapy-based hair solutions
