Treatment Overview
Polynucleotide (PN) Therapy is a regenerative skin treatment widely offered in Korean dermatology clinics. Derived from purified salmon DNA, PNs work by repairing damaged cells, stimulating fibroblasts, and promoting collagen and elastin synthesis. Unlike fillers, which only add volume, PNs strengthen and rejuvenate skin from within, making them ideal for fragile or thinning skin.
For thin skin and skin thinning, PN injections help restore dermal thickness, improve elasticity, and repair UV or age-related damage, leaving the skin stronger, firmer, and more resilient.
Purpose & Benefits
- Dermal Repair: Restores fragile, thinning skin by stimulating cell regeneration.
- Collagen & Elastin Stimulation: Increases skin density and firmness.
- Barrier Strengthening: Improves hydration and protects against further thinning.
- Wrinkle Softening: Reduces fine lines caused by thinning and photoaging.
- Skin Healing: Repairs UV damage and improves long-term resilience.
- Synergy: Works well with Rejuran, Exosomes, Microneedling, or CO₂ Laser.
Ideal Candidates
Polynucleotide therapy in Korea for thin skin and skin thinning is recommended for:
- Adults with fragile, thinning skin due to aging or sun exposure.
- Patients experiencing loss of elasticity, fine wrinkles, or dullness.
- Those seeking a biological skin-regenerating injection instead of synthetic fillers.
Comparison with other treatments:
- Polynucleotide (PN): Best for skin regeneration and dermal repair.
- Rejuran Healer (PN variant): Specialized for DNA-level healing and elasticity.
- Exosome Therapy: Best for cellular-level rejuvenation.
- Collagen Stimulating Fillers: Best for long-lasting dermal thickening.
- MTS Microneedling: Best for natural collagen induction.
Possible Risks & Complications
Polynucleotide injections are safe in expert Korean clinics, but mild side effects may include:
- Redness or Pinpoint Bumps: Common, fade within 24–48 hours.
- Swelling or Bruising: Temporary at injection sites.
- Tenderness: Subtle, resolves in 1–2 days.
- Rare Risks: Allergic reaction (extremely rare).
Surgical Techniques Used
- Micro-Injections: PNs are injected into the dermis using a fine needle.
- Meso-Gun or Syringe: Ensures even distribution across thin or fragile skin areas.
- Targeted Areas: Face, under-eyes, neck, or hands.
- Combination Therapy: Often paired with Exosomes, Rejuran HB, or PRP.
- Protocol: 3–4 sessions every 3–4 weeks; maintenance every 6–12 months.
Recovery & Aftercare
- Immediately: Pinpoint redness or swelling.
- 1–3 Days: Skin calms; hydration and firmness begin to improve.
- 2–4 Weeks: Noticeable improvement in thickness and elasticity.
Aftercare Tips:
- Avoid makeup for 24 hours.
- Apply SPF 50+ daily to protect regenerating skin.
- Use hydrating creams with HA or ceramides.
- Avoid alcohol, saunas, and heavy workouts for 1–2 days.
Results & Longevity
- Short-Term (2–4 Weeks): Improved hydration and glow.
- Medium-Term (2–3 Months): Thicker, firmer, and more elastic skin.
- Long-Term: Results last 6–12 months; regular boosters extend benefits.
Treatment Process in Korea
- Consultation & Skin Analysis – Doctor evaluates thinning and treatment needs.
- Preparation – Cleansing and numbing cream applied.
- PN Injection Session – Even micro-injections across targeted areas.
- Optional Add-Ons – Exosome infusion, Rejuran HB, or PRP.
- Post-Care – Cooling masks, LED therapy, or antioxidant serums.
- Follow-Up – Multi-session plan ensures long-term strengthening.
Why Korea is a Top Destination
- Korea is a pioneer in PN and DNA-based regenerative injectables.
- Clinics use authentic, KFDA-approved PN formulations.
- Dermatologists specialize in combining PN therapy with lasers, exosomes, and boosters.
- More cost-effective compared to Western regenerative treatments.
- Seoul is internationally recognized for skin strengthening and anti-aging programs.
Cost Range (Detailed Breakdown)
Pricing for Polynucleotide injections in Korea for thin skin:
- Single Session: USD 250 – 450
- 3–4 Session Package (recommended): USD 700 – 1,200
- PN + Exosome/Rejuran/PRP Combo: USD 400 – 800 per session
- Premium Anti-Aging Package (PN + Exosomes + Lasers + Fillers): USD 2,000 – 3,500
Additional Costs in Korea:
- Consultation: USD 20 – 40
- Add-ons (Exosomes, Rejuran, PRP, Vitamin Infusions): USD 100 – 500
💡 Patients often call Polynucleotide therapy the “skin DNA repair injection”, since it restores strength, thickness, and resilience in fragile, thinning skin.
Popular Clinics in Seoul
- Banobagi Dermatology – PN + Exosomes for advanced repair.
- Oracle Dermatology – PN + Rejuran for elasticity and thickness.
- Renewme Skin Clinic – Specializes in PN-based rejuvenation for thin skin.
- View Plastic & Dermatology – PN + PRP or laser repair packages.
- Chaum Anti-Aging Center – Premium PN + multi-step regenerative protocols.
