Skin bio revitalization has become one of Korea’s most sought-after aesthetic treatments, especially for those looking to enhance skin texture, hydration, elasticity, and overall glow without altering facial structure. One of the key reasons for its popularity is the advanced skin formulations used in Korean injections — many of which go beyond basic hyaluronic acid (HA).
In this article, we’ll break down the most popular ingredients found in Korean skin bio revitalization injections, including PN, PDRN, HA, and other skin-nourishing components. Understanding each ingredient’s function can help you choose the right treatment for your individual skin concerns.
🧬 1. PN (Polynucleotides)
What It Is:
PN stands for polynucleotides, long chains of DNA fragments derived from salmon sperm. These molecules are purified and bio-compatible, designed to mimic the body’s own cellular material.
Function:
- Stimulates skin cell regeneration
- Repairs damaged tissue
- Improves elasticity and firmness
- Reduces fine lines and acne scars
Featured In:
- Rejuran Healer (PN)
- Rejuran S (for acne scars)
- Rejuran I (for under-eyes)
Best For:
- Aging skin
- Post-laser recovery
- Skin with scars or chronic irritation
🧪 “PN promotes fibroblast activity, helping regenerate the extracellular matrix.” – Dr. Lee, Seoul Dermatology Institute
🔬 2. PDRN (Polydeoxyribonucleotide)
What It Is:
A subtype of PN, PDRN is a smaller DNA fragment that penetrates skin more easily. It’s extracted from salmon DNA and is well-known for its use in wound healing and anti-inflammatory therapy.
Function:
- Speeds skin healing and tissue regeneration
- Reduces inflammation and redness
- Stimulates collagen synthesis
- Enhances vascular circulation
Featured In:
- Placentex
- Rejuran Healer (which combines PN + PDRN)
Best For:
- Red, sensitive, or inflamed skin
- Rosacea-prone skin
- Post-procedure recovery
💧 3. HA (Hyaluronic Acid)
What It Is:
A naturally occurring molecule in the skin that holds up to 1,000 times its weight in water, HA is the gold standard for hydration.
Function:
- Boosts deep skin hydration
- Plumps fine lines
- Strengthens the skin barrier
- Enhances skin smoothness and radiance
Forms Used:
- Non-crosslinked HA: Ideal for skin revitalization (easily absorbed)
- Crosslinked HA: Used in dermal fillers (for volume)
Featured In:
- Skinboosters like Restylane Vital, Juvederm Volite
- Filorga NCTF 135HA (contains non-crosslinked HA + vitamins)
Best For:
- Dehydrated, dull skin
- Early signs of aging
- Loss of radiance
🧪 4. Amino Acids
What They Are:
Building blocks of protein that support skin’s repair, hydration, and elasticity. Korean formulations often contain amino acid blends like glycine, proline, lysine, and arginine.
Function:
- Enhances collagen and elastin production
- Improves skin texture and density
- Supports healing and moisture retention
Found In:
- Filorga NCTF 135HA
- Curenex formulations
🌟 5. Peptides
What They Are:
Short chains of amino acids that act as messengers to promote cellular activities.
Function:
- Stimulates collagen and elastin synthesis
- Improves skin tone and firmness
- Reduces fine lines and signs of fatigue
Found In:
- Curenex Snow Peel
- Cellbooster Glow
Peptides are especially effective when used alongside HA or PDRN for dual-action skin renewal.
🍊 6. Vitamins (A, B, C, E)
What They Do:
- Vitamin C: Brightens, boosts collagen, neutralizes free radicals
- Vitamin B3 (Niacinamide): Strengthens barrier, calms redness
- Vitamin A (Retinol derivatives): Promotes cellular turnover
- Vitamin E: Antioxidant, improves skin resilience
These are typically micro-dosed into the skin with revitalization cocktails to improve tone, pigmentation, and texture.
🧴 7. Coenzymes & Minerals
Coenzymes:
Substances that assist enzymes in energy production and cell metabolism (e.g., NAD+, Q10). They improve cell vitality and support anti-aging processes at a cellular level.
Minerals:
Ingredients like zinc, selenium, and magnesium can support skin detoxification, help fight acne, and improve immune defense of the skin.
💡 Combination Formulations: Korean Favorites
| Product | Key Ingredients | Best For |
|---|---|---|
| Rejuran Healer | PN + PDRN | Anti-aging, healing, scar repair |
| Filorga NCTF 135HA | HA + vitamins + amino acids + coenzymes | Deep hydration, glow, texture refinement |
| Curenex | PDRN + peptides + amino acids | Skin tone, firmness, anti-wrinkle |
| Skinboosters (Restylane, Juvederm) | Non-crosslinked HA | Hydration and elasticity |
🧭 Choosing the Right Cocktail for Your Skin
| Concern | Recommended Ingredients |
|---|---|
| Dullness / Dehydration | Non-crosslinked HA, Vitamin C |
| Aging / Wrinkles | PDRN, peptides, amino acids |
| Sensitive / Damaged Skin | PN, PDRN, B-complex vitamins |
| Acne Scarring | Rejuran S (PN), Retinol derivatives |
| Pigmentation | Vitamin C, Glutathione, Niacinamide |
Korean dermatologists typically conduct skin analysis before customizing the ideal blend for your needs.
🧑⚕️ Final Thoughts: Science-Backed Skin Rejuvenation
Korea’s approach to skin bio revitalization is rooted in scientific innovation, preventive care, and gentle skin regeneration. By combining bio-compatible ingredients like HA, PDRN, and peptides, these injectable treatments offer safe, long-lasting improvements in skin health and appearance.
If you’re considering bio revitalization in Korea, request a consultation to learn which ingredient blend or branded product is best for your skin goals.
