Skin bio revitalization has become a cornerstone of Korean aesthetic dermatology, offering a non-invasive yet powerful solution for patients who want radiant, smooth, and rejuvenated skin. Unlike traditional fillers that add volume, skin bio revitalization works at the cellular level — nourishing the skin from within using a mix of regenerative ingredients.
But what exactly is being injected? In this guide, we explore the most popular and effective ingredients in Korean skin bio revitalization injections, such as PN, PDRN, HA, peptides, and more. Understanding these components will help you make informed decisions about which treatment is best for your skin type and aesthetic goals.
🧬 1. PN (Polynucleotides)
Polynucleotides (PN) are DNA fragments derived from salmon sperm — one of the safest and most biocompatible sources. These high-purity molecules are designed to promote tissue regeneration and healing.
✨ Key Benefits:
- Activates fibroblasts (the cells that produce collagen and elastin)
- Repairs damaged skin structures
- Improves elasticity and dermal thickness
- Reduces fine lines, enlarged pores, and acne scars
📌 Used In:
- Rejuran Healer
- Rejuran S (for acne scarring)
- Rejuran I (for under-eye rejuvenation)
🧑⚕️ Best For:
- Aging or thinning skin
- Sensitive skin types
- Skin with long-term damage (UV exposure, acne)
🔬 2. PDRN (Polydeoxyribonucleotide)
PDRN is a subtype of PN, composed of shorter DNA chains for faster absorption and targeted regeneration. It’s widely used in wound care and regenerative medicine.
✨ Key Benefits:
- Speeds up skin healing
- Reduces inflammation
- Enhances vascular circulation in the dermis
- Boosts collagen synthesis and tissue remodeling
📌 Used In:
- Placentex
- Curenex Rejuvenation Series
- Rejuran Healer (combined with PN)
🧑⚕️ Best For:
- Skin recovery after laser or microneedling
- Inflammatory skin conditions (e.g., rosacea)
- Patients with post-acne pigmentation
💧 3. HA (Hyaluronic Acid)
Hyaluronic acid is a naturally occurring polysaccharide found in the skin, known for its extraordinary water-binding capacity.
✨ Key Benefits:
- Provides intense hydration
- Plumps up fine lines and wrinkles
- Improves skin texture and elasticity
- Supports skin barrier function
📌 Forms:
- Non-crosslinked HA – For deep hydration and skin improvement
- Crosslinked HA – Used mainly in fillers, not skin boosters
📌 Used In:
- Restylane Skinboosters
- Juvederm Volite
- Filorga NCTF 135HA
🧑⚕️ Best For:
- Dehydrated or dull skin
- Early signs of aging
- Smokers or frequent travelers with dry skin
🧪 4. Amino Acids
Amino acids are the building blocks of proteins like collagen and elastin. They play a vital role in cell repair, hydration, and regeneration.
✨ Key Benefits:
- Stimulate collagen production
- Improve cell metabolism
- Strengthen the skin matrix
- Assist in wound healing
📌 Common Types:
- Glycine
- Proline
- Arginine
- Leucine
📌 Used In:
- Filorga NCTF 135HA
- Curenex Rejuvenation Complex
🧑⚕️ Best For:
- Skin laxity and texture irregularities
- Mature or sun-damaged skin
- Complementary use with HA and PDRN
🧬 5. Peptides
Peptides are short chains of amino acids that act as biological messengers, stimulating skin cells to produce more collagen and elastin.
✨ Key Benefits:
- Boost skin firmness
- Reduce wrinkles and fine lines
- Increase skin density
- Enhance cell-to-cell communication
📌 Types Often Used:
- Copper peptides (healing)
- Matrixyl (collagen booster)
- Argireline (wrinkle reduction)
📌 Used In:
- Cellbooster Glow
- Curenex Snow Peel
- Dermaheal SR
🧑⚕️ Best For:
- Fine lines around eyes and mouth
- Sagging skin
- Preventative anti-aging treatments
🍊 6. Vitamins and Antioxidants
Skin bio revitalization cocktails often include essential vitamins to support cellular repair and brighten the skin.
✨ Common Vitamins:
- Vitamin C – Brightens skin, boosts collagen
- Vitamin B3 (Niacinamide) – Improves tone and barrier function
- Vitamin A – Promotes cellular turnover
- Vitamin E – Antioxidant and anti-inflammatory
📌 Used In:
- Filorga NCTF 135HA
- Cytocare 532
- Dermaheal HL (Hair + Scalp)
🧑⚕️ Best For:
- Dull, uneven skin tone
- Pigmentation or melasma
- Oxidative stress and pollution damage
🌿 7. Coenzymes and Trace Elements
Coenzymes like NAD+ and trace minerals such as zinc, selenium, and magnesium help regulate cellular energy and protect against oxidative damage.
✨ Key Benefits:
- Supports cellular metabolism
- Promotes detoxification
- Protects against free radicals
- Improves immune defense of the skin
📌 Used In:
- Filorga NCTF 135HA
- Advanced Meso-cocktails
🧑⚕️ Best For:
- Skin fatigue and stress
- Environmental damage
- Post-surgical skin recovery
💎 Summary Table: Ingredient Benefits
| Ingredient | Primary Function | Best For |
|---|---|---|
| PN | Cellular regeneration | Damaged or aged skin |
| PDRN | Healing + anti-inflammatory | Sensitive or inflamed skin |
| HA | Hydration + volume | Dry, dull, or aging skin |
| Amino Acids | Collagen synthesis | Skin elasticity and firmness |
| Peptides | Skin firming + wrinkle reduction | Mature or sagging skin |
| Vitamins | Brightening + barrier repair | Pigmentation, tone issues |
| Coenzymes/Minerals | Cellular energy, detox | Fatigued or stressed skin |
🔍 How to Choose the Right Ingredients
Choosing the ideal skin revitalization formula depends on:
- Skin condition (dehydration, pigmentation, aging)
- Treatment goals (glow, texture, tightening)
- Lifestyle (frequent travel, sun exposure, pollution)
Korean dermatologists typically offer personalized assessments using skin imaging tools and design custom injection protocols based on your needs.
🧑⚕️ Final Thoughts: Science-Driven Beauty
Korean bio revitalization therapies are built on scientific precision, biocompatible ingredients, and a commitment to preventative skincare. Whether you opt for HA-rich skinboosters or PDRN-based healing formulas, you’re giving your skin the tools it needs to regenerate naturally from within.
For best results, choose a certified Korean skin clinic with experienced injectors and access to authentic, approved formulations.
