Treatment Overview
Rejuran Tone-Up Booster is a next-generation polynucleotide (PN) skin booster, formulated with salmon DNA fragments combined with brightening agents (such as niacinamide and antioxidants) to specifically target pigmentation, dullness, and uneven skin tone.
Unlike standard Rejuran Healer (focused on repair) or Rejuran S (for scars), the Tone-Up Booster is designed to lighten pigmentation, improve radiance, and restore balance while repairing skin at the DNA level.
It belongs to the broader Salmon DNA booster family (Rejuran Healer, Rejuran i, Rejuran S, Plinest, Juvelook, Plenhyage XL):
- Rejuran Tone-Up Booster: Best for pigmentation, glow, and skin tone correction.
- Other Salmon DNA boosters: Focus on healing, scars, elasticity, or hydration.
Purpose & Benefits
- Pigmentation Reduction: Lightens sun damage, melasma, and dark spots.
- DNA Repair: PN heals skin at the cellular level for long-term improvement.
- Radiance & Glow: Boosts skin luminosity, achieving the “glass skin” look.
- Even Skin Tone: Reduces redness and discoloration.
- Wrinkle & Fine Line Care: PN + brightening agents improve overall texture.
- Barrier Strengthening: Enhances skin resilience against environmental stress.
- Synergy with Other Salmon DNA Boosters: Tone-Up focuses on glow, while others (Healer, Plinest, Juvelook) work on scars, wrinkles, and elasticity.
Ideal Candidates
Rejuran Tone-Up Booster in Korea is recommended for:
- Adults in their 20s–50s struggling with dullness, pigmentation, or uneven skin tone.
- Patients with melasma, freckles, or post-inflammatory hyperpigmentation.
- Those comparing Rejuran Tone-Up vs other Salmon DNA boosters:
- Tone-Up Booster: Best for brightening + skin tone correction.
- Rejuran Healer: Best for overall DNA repair and anti-aging.
- Rejuran S: Best for scar remodeling and deep repair.
- Plinest/Juvelook: Best for elasticity, scars, and collagen remodeling.
- Individuals seeking non-laser pigmentation management with anti-aging benefits.
Possible Risks & Complications
Rejuran Tone-Up Booster is safe in Korean dermatology clinics, though minor side effects may include:
- Redness or Pinpoint Marks: Common, resolve in 24–48 hours.
- Mild Swelling or Bruising: Temporary and injection-related.
- Tightness or Tenderness: Usually lasts 1–2 days.
- Rare Risks: Irritation if combined with aggressive pigmentation treatments too close together (lasers/peels).
Techniques Used
- Micro-Injections: PN + brightening complex delivered into the dermis.
- Meso-Gun Delivery: Ensures even distribution across the face.
- Targeted Mapping: Focus on pigmentation zones (cheeks, forehead, under-eyes).
- Combination Therapy: Often paired with other Salmon DNA boosters, PRP, or exosomes.
- Multi-Session Protocol: Typically 3–4 treatments spaced 3–4 weeks apart.
Recovery & Aftercare
- Immediately: Redness or small bumps at injection sites.
- 1–3 Days: Skin calms; hydration and initial brightness appear.
- 2–4 Weeks: Pigmentation fades, glow improves, fine lines soften.
- Maintenance: Every 6–9 months recommended.
Aftercare Tips:
- Avoid makeup for 24 hours.
- Apply SPF 50+ daily (critical for pigmentation care).
- Use gentle brightening serums (Vitamin C, niacinamide).
- Avoid saunas, alcohol, and excessive sun exposure for 1–2 days.
Results & Longevity
- Immediate: Slight radiance and smoother skin feel.
- Short-Term (2–4 Weeks): Noticeable glow, reduced pigmentation, improved tone.
- Medium-Term (2–3 Months): Collagen stimulation + DNA repair brighten and firm the skin.
- Long-Term: Results last 6–9 months, especially when combined with sun care and maintenance.
Treatment Process in Korea
- Consultation & Skin Analysis – Doctor assesses pigmentation, tone, and hydration.
- Preparation – Cleansing and numbing cream applied.
- Injection Session – Rejuran Tone-Up Booster injected via micro-needle or meso-gun.
- Optional Add-On: Other Salmon DNA boosters (Healer, Plinest, Juvelook) for multi-layer repair.
- Post-Care: Cooling masks, LED therapy, soothing serums.
- Follow-Up: 3–4 sessions for best results, then maintenance.
Why Korea is a Top Destination
- Korea is the origin of Rejuran PN injectables, with specialized variants like Tone-Up.
- Clinics use authentic, KFDA-approved Rejuran Tone-Up and Salmon DNA boosters.
- Dermatologists specialize in pigmentation + PN repair combination treatments.
- More affordable compared to Western pigmentation therapies, with advanced techniques.
- Seoul is internationally recognized for brightening and “glass skin” protocols.
Cost Range (Detailed Breakdown)
Pricing for Rejuran Tone-Up Booster in Korea varies by clinic and package:
- Single Session (full face): USD 300 – 600
- 3-Session Package (recommended): USD 900 – 1,500
- Tone-Up + Salmon DNA Combo: USD 700 – 1,500 per session
- Luxury Brightening Package (Tone-Up + PN boosters + PRP/Exosomes): USD 2,000 – 3,800
Additional Costs in Korea:
- Consultation: USD 20 – 50
- Numbing & post-care: USD 20 – 40
- Add-ons (PRP, PDO threads, exosomes): USD 200 – 800
💡 Patients often call Rejuran Tone-Up the “brightening DNA booster”, while other Salmon DNA boosters are known as “repair and elasticity injectables.” Together, they deliver luminous, even-toned, and youthful skin.
Popular Clinics
- Banobagi Dermatology (Seoul): Known for Tone-Up + PN repair combos.
- Oracle Dermatology (Seoul): Offers Tone-Up with Rejuran Healer for glow + repair.
- Renewme Skin Clinic (Seoul): Specializes in pigmentation and PN programs.
- View Plastic & Dermatology (Seoul): Combines Tone-Up with exosomes and PRP.
- Chaum Anti-Aging Center (Seoul): Premium anti-aging + brightening Tone-Up protocols.



