Treatment Overview
Ultra-High Resolution PGT (Preimplantation Genetic Testing) represents the next generation of embryo genetic screening technology, offering unparalleled accuracy in detecting chromosomal and genetic abnormalities before embryo transfer during IVF.
In Korea, fertility centers have integrated ultra-high resolution sequencing, advanced bioinformatics algorithms, and microscale embryo biopsy techniques to perform one of the most comprehensive genetic evaluations available in reproductive medicine today. This advanced testing not only checks for chromosomal aneuploidy (extra or missing chromosomes) but can also detect microdeletions, duplications, mosaicism, and subtle genomic variations that standard tests may overlook.
Korean fertility clinics are recognized globally for pioneering this technology and combining it with state-of-the-art laboratory environments and precision embryology, providing patients with exceptional accuracy, safety, and peace of mind.
Purpose & Benefits
The primary purpose of Ultra-High Resolution PGT is to ensure that only genetically and chromosomally normal embryos are selected for transfer, optimizing pregnancy outcomes and reducing the risk of genetic disorders.
Key Benefits:
- Exceptional genetic precision: Detects the smallest genetic changes across all 23 pairs of chromosomes.
- Improved IVF success rates: Increases the likelihood of implantation and live birth through enhanced embryo selection.
- Reduced miscarriage risk: Identifies embryos with chromosomal abnormalities responsible for early pregnancy loss.
- Micro-level accuracy: Detects submicroscopic deletions and duplications invisible to older technologies.
- Enhanced embryo viability prediction: Combines genetic, morphological, and kinetic data for selection.
- Optimized single embryo transfer (SET): Enables confident selection of one genetically healthy embryo, reducing multiple pregnancy risks.
- Prevention of hereditary disorders: Can identify gene-level abnormalities passed from parents to offspring.
- Peace of mind: Offers couples complete confidence in the genetic health of their embryos.
Korean fertility clinics use this technology as part of a comprehensive approach to reproductive medicine, combining genetics, embryology, and data analytics.
Ideal Candidates
Ultra-High Resolution PGT is suitable for individuals or couples who want the most advanced level of genetic assurance possible, including:
- Women aged 35 and above, at increased risk of chromosomal abnormalities.
- Couples with recurrent miscarriages or previous IVF failures.
- Patients carrying single-gene or structural chromosomal abnormalities.
- Couples with a family history of inherited diseases or genetic syndromes.
- Those using donor eggs or sperm who desire additional screening assurance.
- Cancer survivors or individuals undergoing fertility preservation seeking to ensure future embryo health.
- International patients seeking advanced and accurate embryo testing combined with Korea’s expertise in IVF care.
This test is ideal for patients who value comprehensive precision over basic screening approaches.
Possible Risks & Complications
Ultra-High Resolution PGT is a safe and minimally invasive laboratory procedure, but patients should be aware of potential risks and considerations:
- Embryo biopsy risk: Although minimal, removing cells for testing must be done with extreme precision to avoid affecting embryo viability.
- Mosaicism detection complexity: Identifying partial or mixed genetic abnormalities may yield complex results requiring expert interpretation.
- Emotional considerations: Couples may face difficult decisions if few embryos meet the required criteria.
- Cost implications: Ultra-high resolution sequencing is more expensive than standard PGT methods.
- False negatives or positives: Extremely rare, but possible due to low DNA quantity or biological variability.
- Time delay: Results analysis may extend the time before embryo transfer, requiring cryopreservation.
Korean fertility clinics minimize these risks through strict laboratory standards, advanced biopsy technology, and in-house genetic counseling.
Techniques & Laboratory Methods
Korea’s fertility laboratories employ a combination of advanced genomic and embryologic technologies to achieve ultra-high resolution accuracy:
1. Trophectoderm Biopsy at Blastocyst Stage
Performed on day 5 or 6 embryos, where 5–10 trophectoderm cells (destined to form the placenta) are removed using laser precision, preserving the inner cell mass.
2. Whole-Genome Amplification (WGA)
Amplifies the limited DNA from the biopsy sample to create sufficient material for analysis without losing fidelity.
3. Ultra-High Resolution Next-Generation Sequencing (NGS)
Employs next-generation sequencing with microarray hybridization to map chromosomal segments at ultra-fine resolution—detecting even small deletions or duplications.
4. Bioinformatic Genomic Mapping
Sophisticated software algorithms analyze sequencing data to ensure accurate identification of normal and abnormal chromosomes, structural rearrangements, and mosaicism.
5. Integrated AI-Based Embryo Analysis
Combines genetic results with time-lapse imaging and morphology scoring to rank embryos based on genetic integrity and implantation potential.
6. Cryopreservation (Vitrification)
After biopsy, embryos are vitrified and stored while awaiting results, ensuring safety and preservation of embryo quality.
7. Genetic Counseling & Data Review
Specialized geneticists interpret results, provide a detailed report, and discuss optimal embryo selection with patients and their fertility team.
Korean laboratories combine clinical-grade sequencing with automation and robotics to achieve near-perfect accuracy rates in genetic diagnosis.
Recovery & Aftercare
The Ultra-High Resolution PGT process occurs entirely in the laboratory, requiring minimal recovery time for patients.
Aftercare Process:
- Post-egg retrieval: Mild rest and recovery from standard IVF egg collection.
- Awaiting results: Biopsied embryos are safely frozen; results are typically ready within 7–10 days.
- Genetic counseling session: Couples meet with specialists to review genetic findings and embryo suitability.
- Frozen Embryo Transfer (FET): Once a chromosomally normal embryo is confirmed, the transfer is scheduled in a hormonally optimized cycle.
- Emotional and psychological support: Many clinics offer counseling services to guide patients through the emotional aspects of embryo selection.
Patients generally resume normal activities immediately following the IVF retrieval and biopsy stages.
Results & Longevity
Korea’s Ultra-High Resolution PGT programs have demonstrated impressive results and reliability:
- Implantation rates: 65–75% for genetically normal embryos.
- Miscarriage reduction: Up to 70% decrease in pregnancy loss due to chromosomal abnormalities.
- Accuracy rate: Exceeds 99% for detecting chromosomal aneuploidies and micro-level genetic defects.
- Healthy live births: High correlation between screened embryos and successful full-term pregnancies.
- Long-term stability: Cryopreserved embryos remain viable and genetically stable for many years.
- Fewer IVF cycles required: Enhanced embryo selection minimizes the need for multiple cycles.
The long-term success and safety of embryos tested through this program are well-supported by Korean clinical research and patient outcomes.
Treatment Process in Korea
Step 1 – Consultation & Genetic Evaluation
- Assessment of patient medical history, age, and genetic risks.
- Determination of suitability for ultra-high resolution PGT.
Step 2 – IVF Stimulation & Egg Retrieval
- Controlled ovarian stimulation and oocyte retrieval.
- Eggs fertilized via ICSI to ensure clean DNA testing.
Step 3 – Embryo Culture & Biopsy
- Embryos cultured to blastocyst stage (day 5–6).
- Trophectoderm biopsy performed by embryologists using micro-laser technology.
Step 4 – Genetic Analysis
- Ultra-high resolution NGS and WGA performed to detect even the smallest chromosomal and genetic abnormalities.
Step 5 – Genetic Reporting & Counseling
- Comprehensive embryo report provided.
- Embryos classified as euploid (normal), aneuploid (abnormal), or mosaic (mixed).
Step 6 – Frozen Embryo Transfer
- Only chromosomally normal embryos transferred in a subsequent frozen cycle.
Why Korea Leads
- Cutting-edge genomic laboratories with the latest sequencing and microarray systems.
- Highly skilled embryologists and genetic scientists with international accreditation.
- Integration of AI, robotics, and genomics in clinical practice.
- Comprehensive international patient services with transparent treatment plans.
- Excellent success rates and quality control through advanced technology and multidisciplinary collaboration.
Korea’s combination of technology, expertise, and compassionate care makes it one of the leading destinations for reproductive genetics worldwide.
Cost Range
The cost of Ultra-High Resolution PGT in Korea varies based on the number of embryos tested and clinic expertise:
- PGT (Ultra-High Resolution Sequencing): USD 4,000 – 8,000
- Embryo Biopsy & Vitrification: USD 1,500 – 2,500
- IVF Treatment (Stimulation & Egg Retrieval): USD 6,000 – 10,000
- Frozen Embryo Transfer (FET): USD 2,000 – 4,000
- Annual Cryostorage Fee: USD 300 – 700
- Genetic Counseling & Consultation: USD 300 – 500
Comprehensive IVF + Ultra-High Resolution PGT packages typically range between USD 10,000 and USD 16,000, depending on the complexity of testing and clinic.
Popular Clinics in Korea
- CHA Fertility Center (Seoul / Bundang): Known for advanced genomic sequencing and precise embryo selection.
- Maria Fertility Hospital: Offers extensive genetic analysis programs integrated with IVF.
- MizMedi Women’s Hospital: Specializes in high-resolution genetic testing and cryopreservation.
- Hamchoon Women’s Clinic: Recognized for genetic and embryology excellence.
- Seoul National University Fertility Center: Combines academic research with cutting-edge genetic testing.
