Treatment Overview
The Whole-Genome Embryo Test (WGET) represents the most advanced level of Preimplantation Genetic Testing (PGT) available in modern fertility care. Unlike traditional PGT methods that focus on a limited set of chromosomes or specific mutations, the Whole-Genome Embryo Test analyzes the complete genetic blueprint of each embryo before implantation.
In Korea, fertility centers have perfected this cutting-edge testing process using next-generation sequencing (NGS), whole-genome amplification (WGA), and AI-supported bioinformatics to map the entire genome of embryos created through IVF. This allows physicians to detect not only chromosomal abnormalities and single-gene disorders but also microdeletions, duplications, and genetic variations that could influence long-term health and development.
Korean fertility clinics are at the forefront of implementing whole-genome embryo testing as part of comprehensive reproductive medicine programs — combining accuracy, technology, and world-class embryology to ensure the healthiest possible start to life.
Purpose & Benefits
The goal of Whole-Genome Embryo Testing is to provide couples with complete genetic insight into their embryos before implantation, enabling truly personalized and predictive reproductive care.
Key Benefits:
- Comprehensive genomic coverage: Evaluates every chromosome and gene, not just selected regions.
- Detection of hidden mutations: Identifies submicroscopic genetic variations missed by conventional PGT-A or PGT-M.
- Enhanced embryo selection: Prioritizes embryos with optimal genomic stability and low-risk genetic profiles.
- Reduced miscarriage risk: Screens for chromosomal errors that commonly cause early pregnancy loss.
- Increased IVF success rates: Enables selection of the healthiest embryo, improving implantation and live birth rates.
- Early detection of potential hereditary risks: Allows couples to make informed reproductive decisions.
- Optimized single embryo transfer (SET): Promotes safe, high-confidence embryo selection for single transfers.
- Supports long-term family health: Offers predictive insights into future health risks and resilience markers.
In Korea, the integration of full-genome sequencing with advanced embryology represents a transformative leap forward in reproductive precision and patient assurance.
Ideal Candidates
The Whole-Genome Embryo Test is particularly beneficial for:
- Couples with a family history of genetic or chromosomal disorders.
- Women over the age of 35, who have higher chances of chromosomal abnormalities in eggs.
- Patients with recurrent miscarriage or failed IVF cycles.
- Carriers of genetic mutations or chromosomal rearrangements.
- Couples who have previously experienced pregnancies affected by genetic diseases.
- Patients using donor eggs or sperm seeking comprehensive genetic screening.
- Cancer survivors undergoing fertility preservation and wishing to ensure healthy embryo genetics.
- International patients seeking advanced and precise reproductive genomic testing.
By offering whole-genome data, Korean fertility programs tailor embryo selection and IVF treatment to each couple’s unique genetic profile.
Possible Risks & Complications
Although the Whole-Genome Embryo Test is considered safe and reliable, there are certain considerations patients should be aware of:
- Embryo biopsy precision: The removal of a few cells for testing carries minimal risk when performed by expert embryologists.
- Mosaicism: Some embryos may show mixed chromosomal profiles, complicating result interpretation.
- Data interpretation complexity: The vast amount of genetic information requires skilled analysis and counseling.
- Emotional stress: Patients may face complex decisions when genetic results reveal uncertain or unexpected findings.
- Additional cost: Whole-genome sequencing is more expensive than standard PGT.
- Extended IVF timeline: Results analysis and data review may add a short delay before embryo transfer.
Korean fertility centers minimize these risks through rigorous laboratory standards, genetic counseling, and transparent patient education.
Techniques & Laboratory Methods
The Whole-Genome Embryo Test uses cutting-edge molecular and computational technologies integrated into IVF laboratory procedures:
1. Trophectoderm Biopsy (Day 5–6 Blastocyst Stage)
A few trophectoderm cells are carefully extracted using laser-assisted microtools while preserving the inner cell mass (which forms the fetus).
2. Whole-Genome Amplification (WGA)
DNA from the sampled cells is amplified to generate sufficient material for sequencing without altering the original structure.
3. Next-Generation Sequencing (NGS)
Sequencing machines read billions of DNA fragments to reconstruct the embryo’s entire genome, providing comprehensive data on all chromosomes and genes.
4. Variant and Mutation Analysis
Software identifies variations such as deletions, duplications, aneuploidies, and single nucleotide changes that could affect embryo health.
5. Bioinformatic Interpretation
AI and bioinformatics experts analyze results to assign each embryo a genetic health score based on known medical correlations and chromosomal stability.
6. Genetic Counseling Integration
Specialists review findings with the couple, explaining detected variants, inheritance risks, and implications for embryo selection.
7. Cryopreservation and Embryo Ranking
Embryos are vitrified while results are analyzed. After review, the most genetically stable embryo is selected for transfer.
This combination of precision sequencing and expert analysis allows Korean clinics to provide one of the most complete embryo assessments available globally.
Recovery & Aftercare
The physical recovery following embryo biopsy and IVF remains minimal. However, genetic counseling and psychological support play an essential role in patient aftercare.
Aftercare Process:
- Post-egg retrieval rest: Light activity for 1–2 days; mild discomfort is normal.
- Embryo cryopreservation: Biopsied embryos are frozen while sequencing and analysis are completed.
- Results consultation: A detailed report is reviewed with genetic counselors and fertility specialists.
- Frozen Embryo Transfer (FET): Once a healthy embryo is confirmed, transfer is scheduled in a hormonally prepared cycle.
- Monitoring and support: Hormone tracking and early pregnancy monitoring continue post-transfer.
Korean fertility clinics emphasize holistic aftercare, combining emotional well-being with advanced clinical monitoring for optimal pregnancy outcomes.
Results & Longevity
Whole-genome embryo testing offers exceptional accuracy and long-term advantages:
- High precision: Over 99% accuracy in identifying chromosomal and gene-level abnormalities.
- Higher pregnancy success rates: Embryos selected using full-genome analysis have significantly improved implantation outcomes.
- Reduced miscarriage rates: Early detection of chromosomal errors lowers early pregnancy loss.
- Healthy live births: Ensures only chromosomally balanced embryos are transferred.
- Predictive health insights: Enables proactive planning for inherited disease prevention.
- Longevity of embryo viability: Vitrified embryos maintain genomic stability for many years under proper storage.
- Personalized fertility strategies: Genetic results can guide future IVF planning or donor selection.
Korean fertility centers report consistently high success rates using whole-genome embryo testing as part of a personalized reproductive care approach.
Treatment Process in Korea
Step 1 – Pre-IVF Consultation & Genetic Evaluation
- Review of patient and family genetic history.
- Discussion of reproductive goals and suitability for whole-genome testing.
Step 2 – Ovarian Stimulation & Egg Retrieval
- Customized stimulation protocol based on age and ovarian reserve.
- Egg retrieval performed under mild sedation.
Step 3 – Fertilization & Embryo Culture
- Eggs fertilized via ICSI for precision.
- Embryos cultured to the blastocyst stage under optimal laboratory conditions.
Step 4 – Embryo Biopsy & DNA Sequencing
- Trophectoderm biopsy performed on day 5–6.
- DNA samples undergo whole-genome amplification and next-generation sequencing.
Step 5 – Genetic Data Analysis
- Bioinformatics team analyzes genome data for chromosomal, structural, and single-gene abnormalities.
- Genetic health profiles generated for each embryo.
Step 6 – Embryo Selection & Transfer
- Euploid and genetically balanced embryos prioritized.
- Frozen embryo transfer performed in a hormonally synchronized cycle.
Why Korea Leads
- Pioneering genomic infrastructure with access to full-genome sequencing technologies.
- Highly experienced embryologists and geneticists collaborating in integrated fertility programs.
- AI-driven genetic interpretation for precision embryo ranking.
- Ethical and transparent patient care backed by advanced clinical governance.
- Global reputation for excellence in IVF, PGT, and fertility innovation.
Korea’s unique integration of medical science, data analytics, and patient-centered care has established it as a world leader in reproductive genomics.
Cost Range
The cost of Whole-Genome Embryo Testing in Korea varies depending on the number of embryos analyzed and the depth of genomic analysis:
- Whole-Genome Sequencing (WGET): USD 5,000 – 8,000
- Embryo Biopsy & Cryopreservation: USD 1,500 – 2,500
- IVF Cycle (stimulation, retrieval, culture): USD 6,000 – 10,000
- Frozen Embryo Transfer (FET): USD 2,000 – 4,000
- Genetic Counseling & Data Review: USD 300 – 600
- Annual Embryo Storage: USD 300 – 700
Comprehensive IVF + Whole-Genome Testing packages generally range from USD 10,000 to 16,000, depending on clinic and complexity.
Popular Clinics in Korea
- CHA Fertility Center (Seoul / Bundang): Leader in full-genome embryo testing and precision reproductive genetics.
- Maria Fertility Hospital: Specializes in high-level genomic fertility programs.
- MizMedi Women’s Hospital: Offers advanced sequencing and embryo analysis systems.
- Hamchoon Women’s Clinic: Focuses on comprehensive PGT and genetic counseling integration.
- Seoul National University Fertility Center: Combines academic research with clinical excellence in genomics.
